长期服用抗癫痫药物对原发性癫痫患者平均血红蛋白含量的影响

Effect of antiepileptic drugs on mean corpuscular hemoglobin in patients with essential epilepsy

目的探讨长期服用抗癫痫药物对癫痫患者平均血红蛋白含量的影响。方法回顾性分析54例长期服用抗癫痫药物的原发性癫痫患者红细胞数,红细胞比容,平均血红蛋白含量,以同时期门诊健康体检者30例为对照组。结果长期服用抗癫痫药物的原发性癫痫患者手术前红细胞数,红细胞比容与正常组无差别(P>0.05),平均血红蛋白含量高于对照组(P<0.01);与性别无关。结论长期服用抗癫痫药物可以导致患者平均血红蛋白含量增高,对这类患者给予叶酸和维生素B12的补充,可能会改善癫痫患者脑内缺氧的状态,缓解癫痫的发作。

Objective To research the effect of antiepileptic drugs on mean corpuscular hemoglobin in patients with essential epilepsy.Methods A total of 54 patients with essential epilepsy who had been taking antiepileptic drugs for long term were enrolled into trial group,and 30 healthy volunteers were enrolled into control group.We retrospectively analyzed such parameters as red blood cell count,volume packed cells and mean corpuscular hemoglobin.Results There were no significant differences in red blood cell count and volume packed cells between the two groups（P0.05）.Mean corpuscular hemoglobin level was significant higher in the trial group than in the control group（P0.05）,and the difference was not relative to gender.Conclusion Long-term intake of antiepileptic drugs increases the mean corpuscular hemoglobin in epilepsy patients.To supply them folic acid and vitamin B（12） may improve their brain hypoxia and decrease seizure.