肝病患者血清前白蛋白和白蛋白的检测及临床意义

Serum prealbumin and albumin tests in patients with liver diseases and their clinical significance

目的探讨血清前白蛋白和白蛋白的检测在肝病中的临床意义。方法对285例肝病患者的血清前白蛋白和白蛋白进行测定,并对检测结果进行比较分析。结果各组肝病患者的血清前白蛋白检测结果之间比较差异有统计学意义(P<0.05);各组肝病患者的血清白蛋白检测结果之间比较差异有统计学意义(P<0.05);急性肝炎组的血清前白蛋白和白蛋白的异常率均低于肝硬化组和肝癌组,与该两组结果比较差异有统计学意义(P<0.05);各组肝病患者的血清前白蛋白与白蛋白检测水平均呈正相关(P<0.05)。结论与血清白蛋白相比较,血清前白蛋白更能灵敏地反映肝细胞损害,可作为判断急性肝脏损害及蛋白合成功能的灵敏指标。

Objective To investigate the clinical significance of serum prealbumin and albumin tests in patients with liver diseases.Methods Serum prealbumin and albumin were assayed in 285 patients with liver diseases and comparatively analyzed.Results There were significant differences both in serum prealbumin and in albumin levels among the groups of various liver diseases（P0.05）.The abnormal rates of serum prealbumin and albumin were significantly lower in acute hepatitis group than in cirrhosis group and liver cancer group（P0.05）.There existed a positive correlation between serum prealbumin and albumin in each group of patients with liver diseases（P0.05）.Conclusion Serum prealbumin,which reflects the hepatocyte lesion more sensitively,can be used as a sensitive indicator for the acute hepatic lesion and the function of protein synthesis.