帕瑞昔布预防全麻术后躁动和咽喉痛的临床研究

Effect of parecoxib on preventing postoperative restlessness and sore throat

目的观察帕瑞昔布预防全麻术后躁动和咽喉痛的有效性。方法40例择期行经腹全子宫切除术的患者,随机分为帕瑞昔布组(P组,n=20)和对照组(C组,n=20)。全麻插管后分别静注帕瑞昔布40mg和相同容量的生理盐水。记录手术时间、麻醉时间、拔管时间,并测定拔管前两组患者苏醒期间的躁动评分,记录术后24h咽喉痛发生率及疼痛评分,观察有无恶心呕吐、术后低氧血症、反流误吸等不良反应。结果两组患者的手术时间、麻醉时间、拔管时间、术后低氧血症、恶心呕吐发生率差异无统计学意义。躁动评分:P组为10%,明显优于C组40%(P<0.01)。咽喉疼痛VAS评分:P组为0.97±1.06,明显低于C组2.79±1.46,P<0.01。结论术前静注帕瑞昔布40mg可有效预防全麻术后躁动和咽喉痛,且不增加不良反应。

Objective To study the preventive effect of parecixib on postoperative restlessness and sore throat.Methods Forty patients undergoing selective hysterectomy were allocated randomly into two groups：group P（20 cases）was administered with parecoxib 40 mg intravenously after induction,group C（20 cases）was given the same volume of saline.The time of surgery,anesthesia and extubation were recorded.The restlessness scores during palinesthesia were evaluated.The rates of sore throat,VAS of sore throat were assessed at 24 h after surgery.Adverse effects were also recorded.Results There was no significant difference in the time of surgery,anesthesia and extubation and occurrence of postoperative hypoxemia,nausea and vomiting between two groups.The rates of restlessness decreased from 36.7% to 5.6%.VAS of sore throat were significantly less in group P（0.97±1.06）than that in group C（2.79±1.46）.Conclusion Injection of parecoxib 40 mg/kg before operation produces a favorable sedation effect without complication.