区域性灌注体毛药液治疗老年肝癌38例报道

Regional infusion of autologous hair granules as embolic agent for the treatment of hepatic carcinoma in the elderly

目的探讨一种新的末梢动脉栓塞剂，减少栓塞盲区。方法将粉碎灭菌的自体毛发颗粒混入抗癌药液及水性造影剂，经导管灌入靶动脉，对３８例老年中晚期肝癌病人进行栓塞化疗结果影像学证实发丝样肿瘤血管及肿瘤染色消失，肿瘤直径缩小５０％以上者７３．７％（２８／３８），缩小２５％～５０％者２１．０％（８／３８），肿瘤无变化或缩小２５％以下者５．３％（２／３８）。ＡＦＰ下降者８１．６％（３１／３８）。６、１２、１８、２４个月生存率分别为１００％、８３．３％、７５％、６６．７％。临床症状及肝功能均有改善。所有病人均未发生异位误栓及排异反应，栓塞后综合征轻微。

Objective Auto hair granules were introduced and evaluated as a new embolic agent that could reduce the embolic blind area in transcatheter arterial embolization(TAE). Methods Autologous hair of the patient was crushed and sterilized.The granular hair was combined with certain anticancer drug and contrast medium.They were then infused into the target artery by catheter for the treatment of middle and advanced hepatic carcinoma in 38 elderly patients. Results Image examination indicated that the filamentous tumor vessels and the tumor staining disappeared after TAE.28 cases showed a more than 50%reduction in tumor diameter as compared with the original size,8 cases showed a 25%～50% reduction and 2 cases showed 0～25% reduction.The clinical manifestation and hepatic function had a significant improvement in all the cases.The level of serum AFP was decreased in 31 cases(81 6%).The survival rates in 6,12,18 and 24 months were 100%,83 3%,75 0% and 66 7%,respectively.Not a single case developed ecto embolism and repellent reaction.The side effects were negligible. Conclusions Autologous hair granules may be regarded as a safe and effective perpetual embolic agent for the treatment of hepatic carcinoma in the elderly.