短期胰岛素强化治疗对初诊2型糖尿病患者胰岛功能的影响

Impact of Short-Term Insulin Intensive Therapy on Pancreatic Islets Function for T2DM Patients at the Initial Visit

目的观察短期胰岛素强化治疗对初诊2型糖尿病(T2DM)患者胰岛β细胞功能的影响。方法将56名FBG≥11.1 mmol/L和2 h BG≥16.7 mmol/L的初诊2型糖尿病患者随机分为短期持续性皮下胰岛素泵(CSII)组及多次胰岛素皮下注射(MSII)组治疗14 d。治疗前和治疗后分别进行FBG、FIns、FC-P、2 h BG、2 h C-P的测定。结果两组病例治疗后FBG均降低,FC-P、FIns均增加,差异有统计学意义。结论短期胰岛素强化治疗可显著改善初诊2型糖尿病患者的胰岛功能。

Objective To observe the impact of short-term insulin intensive therapy on pancreatic islets β cell in T2DM patients at the initial visit.Methods 56 cases of T2DM,in which,FBD≥11.1 mmol/L and 2 h BG≥16.7 mmol/L at the initial visit,were randomized into short-term persistent subcutaneous insulin pump group（CSII）and multiple insulin subcutaneous injection group（MSII）and were treated for 14 days.FBG,Fins,FC-P,2 h BG and 2 h C-P were detected before and after treatment separately.Results FBG decreased in either group after treatment,and FC-P and Fins increased,indicating significant statistical differences.Conclusion The short-term insulin intensive therapy improves pancreatic islets function significantly in T2DM patients at the initial visit.