涎腺导管癌雄激素受体、GCDFP-15及C-erbB-2的表达及意义

Expression of AR、GCDFP-15 and C-erbB-2 in Salivery Duct Carcinoma and their Clinical Significance

目的探讨涎腺导管癌中雄激素受体(AR)、癌基因(C-erbB-2)及巨囊性病液体蛋白(GCDFP-15)的表达及意义.方法用免疫组化方法检测涎腺导管癌组织中AR、C-erbB-2及GCDFP-15的表达情况,以涎腺多形性腺瘤和涎腺囊肿作对照.结果涎腺导管癌中AR、C-erbB-2及GCDFP-15均75%阳性表达,AR、C-erbB-2及GCDFP-15在涎腺多形性腺瘤及涎腺囊肿阳性表达率分别为0%、50%、0%,在涎腺囊肿中的表达分别为0%、0%、0%.三者差异有统计学意义(P<O.05).结论GCDFP-15和C-erbB-2可作为涎腺导管癌的病理学诊断的一个重要标志物.

Objective To investigate the expression of AR,C-erbB-2 and GCDFP-15 in salivery duct carcinoma（SDC） and their clinical significance.Methods Immunohistochemical staining was used to detect the expression of VEGF,GCDFP-15 and C-erbB-2 in SDC,and compared with both pleomorphic adenoma of salivary gland and sialocele.Results Immunohistochemical staining for AR,GCDFP-15 and C-erbB-2 were 75% positive in all SDC,while 0%,50% and 0% in pleomorphic adenoma of salivary gland and 0%,0%and 0% in sialocele respectively,there was a statistic significance among those（P0.05）.Conclusions GCDFP-15 and C-erbB-2 may be used as markers for pathological diagnosis of SDC.