Ezrin在人脑星形细胞瘤中的表达及意义

Expression and significance of Ezrin in human brain astrocytoma

目的探讨Ezrin在人脑星形细胞瘤中的表达及意义。方法免疫组化法检测107例星形细胞瘤和10例正常脑组织中Ezrin的表达，结合临床随访资料分析其表达与预后的相关性。结果Ezrin的表达在2组之间的差异有统计学意义（P〈0．05）。星形细胞瘤中Ezrin阳性表达率为89．7％，其表达与肿瘤恶性程度呈正相关（r=0．551，P〈0．01），临床资料分析发现Ezrin的表达与肿瘤细胞分化、瘤周水肿程度有关（P〈0．05）。Ezrin强阳性表达组和弱阳性＋阴性表达组的术后无瘤生存时间之间差异具有统计学意义（x2=29．85，P=0．000）。结论Ezrin的表达与星形细胞瘤的恶性程度相关，过表达对肿瘤发展起重要作用。

Objective To investigate the expression and significance of Ezrin in human brain astrocytoma. Method Expression of Ezrin in normal human brain tissues of 10 autopsies and tissues of 107 human astrocytomas was examined by immunohistochemical staining. The analysis of clinicopathologic data was performed to reveal the association between the expression of Ezrin and prognosis of patients. Results The expression of Ezrin was significantly higher in human astrocytoma tissues than that in normal brain tissues（ P 〈 0. 05）. In 107 cases of human astrocytomas, the Ezrin expression of 96 cases（89.7% ） were positive. The increase of the expression of Ezrin was correlated positively with tumor grades （ r = 0. 551, P 〈 0. 01 ） . The analysis of clinicopathologic data revealed that the postoperative tumor - free survival time was significantly different between the group with strong positive Ezrin expression and another group with weak positive and negative Ezrin expression （ X2 = 29. 85, P = 0. 000 ）. Conclusions Ezrin immunoreactivity is significantly associated with the malignancy of human astrocytoma. Enhanced ezrin expression maybe play an important role in the development of astrocytoma. Ezrin may provide a useful tool for grading of astrocytoma, and maybe a valuable molecular marker of the prognosis.