摘要
以易得的5-硝基-2-氯苯腈为原料,经水合肼还原,采用改进的Schiemann反应氟化和碱性水解得到5-氟水杨酸,总收率达55.7%.
5-fluorosalieylic acid was prepared from 2-chloro-benzonitrile by nitration, reduction with hy- drazine hydrate, which was converted to 5-fluoro-2-chlorobenzonitrile through improved Schiemann reaction and then hydrolyzation with NaOH with an overall yield of 55.7%.
出处
《湘潭大学自然科学学报》
CAS
CSCD
北大核心
2010年第1期54-56,共3页
Natural Science Journal of Xiangtan University
基金
湖南省教育厅项目(03C461)
关键词
氟化
还原
水解
5-氟水杨酸
fluoronation
reduction
hydrolysis
5-fluorosalicylic acid