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5-氟水杨酸的合成

Synthesis of 5-Fluorosalicylic Acid
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摘要 以易得的5-硝基-2-氯苯腈为原料,经水合肼还原,采用改进的Schiemann反应氟化和碱性水解得到5-氟水杨酸,总收率达55.7%. 5-fluorosalieylic acid was prepared from 2-chloro-benzonitrile by nitration, reduction with hy- drazine hydrate, which was converted to 5-fluoro-2-chlorobenzonitrile through improved Schiemann reaction and then hydrolyzation with NaOH with an overall yield of 55.7%.
作者 陈红飙 史新路 申理滔
机构地区 湘潭大学化学学院环境友好化学与应用教育部重点实验室
出处 《湘潭大学自然科学学报》 CAS CSCD 北大核心 2010年第1期54-56,共3页 Natural Science Journal of Xiangtan University
基金 湖南省教育厅项目(03C461)
关键词 氟化 还原 水解 5-氟水杨酸 fluoronation reduction hydrolysis 5-fluorosalicylic acid
分类号 O641.0 [理学—物理化学]
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参考文献9

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二级参考文献36

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湘潭大学自然科学学报
2010年 第1期

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