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内皮细胞增殖标志物Endoglin和PTEN基因在肿瘤新生血管形成的作用

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摘要 实验表明，肿瘤是血管生成依赖性的。当实体肿瘤的大小超过1～2mm^3时就需要不断地有新生血管形成为肿瘤提供养分、促进肿瘤细胞增殖和侵袭。研究发现，肿瘤血管内皮细胞的增生速度比正常组织细胞快20～2000倍。作为转化生长因子β（TGF-β）家族受体复合物成分之一的Endoglin及抑癌基因PTEN在肿瘤血管的生成中起着非常重要的作用。
作者 朱桢 于笑涵 张素华
机构地区 河北省唐山市协和医院皮肤科 华北煤炭医学院冀唐学院 华北煤炭医学院病理教研室
出处 《中国医药》 2010年第5期481-482,共2页 China Medicine
关键词 ENDOGLIN PTEN 肿瘤新生血管 内皮细胞
分类号 R730.231 [医药卫生—肿瘤]
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参考文献16

  • 1Van den Dfiesche S, Mummery CL, Westermann CJ. Hereditary hemorrhagic telangiectasia:an update on transforming growth factor beta signaling in vasculogenesis and angiogencsis. Cardiovase Res, 2003, 58(1): 20-31.
  • 2Gibbs CP, Kukekov VG, Reith JD, et al. Stem like cells in bone sarcomas : implications for tumorigenesis. Neoplasia,2005,7 ( 11 ) : 967-976.
  • 3Bertolino P, Deckers M, Lebrin F, et al. Transforming growth factor-betasignal transduction in angiogenesis and vascular disorders. Chest ,2005,128 (6 Suppl) :585s-590s.
  • 4Tanaka F, Otake Y, Yanagihara K, et al. Evaluation of angiogenesis in non-small cell lung cancer: comparison between anti-CD34 antibody and anti-CD105 antibody. Clin Cancer Res, 2001,7 ( 11 ) :3410-3415.
  • 5Nachtigal P, Pospisilova N, Veeerova L, et al. Atorvastatin Increases Endoglin, SMAD2, Phosphorylated SMAD2/3 and eNOS Expression in ApoE/LDLR Double Knockout Mice. J Atheroscler Thromb, 2009,16(3) : 265-274.
  • 6Yao Y, Pan Y, Chen J, et al. Endoglin ( CD105 ) expression in angiogenesis of primary hepatocellular carcinomas: analysis using tissue microarrays and comparisons with CD34 and VEGF. Ann Clin Lab Sci ,2007,37 ( 1 ) :39-48.
  • 7Tian F, Zhou AX, Smits AM, et al. Endothelial cells are activated during hypoxia via endoglin/ALK-1/SMAD1/5 signaling in vivo and in vitro. Biochem Biophys Res Commun, 2010,392 ( 3 ) : 283- 288.
  • 8Randall LM, Monk B J, Darcy KM, et al. Markers of angiogenesis in high-risk, early-stage cervical cancer: A Gynecologic Oncology Group study. Gynecol Oncol,2009,112 (3) :583-589.
  • 9江忠清,钟莉娉,曲军英,郑秀,林岷.Endoglin与血管内皮生长因子和血管内皮生长因子受体2及基质金属蛋白酶9联合表达与宫颈癌血管生成的关系[J].中国医药,2009,4(11):838-841. 被引量：4
  • 10王树兴,于春玲,纪宇明,徐希春,辛玲,姜慧峰.星形细胞瘤组织CD105与TGF-β_1的表达及意义[J].临床和实验医学杂志,2009,8(1):1-2. 被引量：2

二级参考文献30

  • 1马军,郭敏,李印,唐芙爱,虎建恩,段芳龄.食管鳞癌中TGF-β及其受体调节成分Endoglin/CD105的表达[J].第四军医大学学报,2006,27(14):1308-1311. 被引量：4
  • 2Bellone G, Solerio D, Chiusa L, et al. Transforming growth factor-beta binding receptor endoglin ( CD105 ) expression in esophageal cancer and in adjacent nontumorous esophagus as prognostic predictor of recurrence [ J ]. Ann Surg Oncol, 2007,14 ( 11 ) :3232 - 3242.
  • 3El-Gohary YM, Silverman JF, Olson PR, et al. Endoglin ( CD105 ) and vascular endothelial growth factor as prognostic markers in prostatic adenocarcinoma[ J ]. Am J Clin Pathol,2007 ,127 (4) :572 - 579.
  • 4Gibbs CP, Kukekov VG, Reith JD,et al. Stem-like cells in bone sarcomas : implications for tumorigenesis [ J ]. Neoplasia, 2005,7 ( 11 ) :967 -976.
  • 5Bodey B, Bodey B Jr, Siegel SE, et al. Over-expression of endoglin ( CD105 ) : a marker of breast carcinoma-induced neo-vascularization [J]. Anticancer Res, 1998,18(5A) :3621 -3628.
  • 6Kumar S, Ghellal A, Li C, et al. Breast carcinoma : vascular density determined using CD105 antibody correlates with tumor prognosis [J]. CancerRes, 1999, 59(4) :856 -861.
  • 7Sehirmning R, Marine D. Endoglin ( CD105 ) expression in squamous cell carcinoma of the oral cavity[ J]. Head Neck,2002,24(2) :151 -156.
  • 8Munoz R, Arias Y, Ferreras JM, et al. Targeting a marker of the turnout neovasculature using a novel anti-human CD105-immunotoxin containing the non-toxic type 2 ribosome-inactivating protein nigrin b [ J ] , Cancer Lett, 2007, 256 ( 1 ) :73 - 80.
  • 9Lee SH, Mizutani N, Mizutani M, et al. Endoglin (CD105) is a target for an oral DNA vaccine against breast cancer[ J] ,Cancer Immunol Immanother, 2006, 55 (12) : 1565 - 1574.
  • 10Seon BK, Takahashi N, Haba A, et al. Angiogenesis and metastasis marker of human tumors[J]. Rinsho Byori ,2001,49(10) :1005 -1013.

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中国医药
2010年 第5期

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