晚期鼻咽癌的原癌基因c-MetmRNA表达与其生物学行为及预后的关系

Correlation between the expression of c-MetmRNA in advanced nasopharyngeal carcinoma and its biological behavior and prognosis.

目的探讨晚期鼻咽分化型非角化性鳞癌中c-metmRNA的表达与生物学行为及预后的关系。方法应用原位杂交检测晚期鼻咽分化型非角化性鳞癌标本55例c-metmRNA的表达。结果55份晚期鼻咽分化型非角化性鳞癌中,总阳性率为65.5%(35/55),生存期在5年以下的患者c-metmRNA高表达占8.6%(18/37),5年以上患者占16.7%(3/18),两组间差异有统计学意义(x2=5.25、P<0.05)。c-metmRNA表达在有颅底侵袭组为74.4%(32/43),无颅底侵袭组为33.3%(4/12),两组间差异有统计学意义(P<0.05)。c-metmRNA表达在颅神经损伤组为77.7%(35/45),无颅神经损伤组为10.0%(1/10),两组间差异有统计学意义(P<0.05)。结论本组晚期鼻咽分化型非角化性鳞癌患者中c-metmRNA的表达与其侵袭有密切的关系,c-met在鼻咽癌的预后中有重要价值,可作为临床治疗、预后的参考指标。

Objective To investigate c -MetmRNA expression in advanced nasopharyngeal differentiated non - keratinizing squamous carcinoma （DNKSC） and their correlation with biological behavior and prognesis. Methods In situ hybridisation was used to detect mRNA expession of c - Met in 55cases DNKSC. Results The expression c - MetmRNA showed general positive rates of 65.5% （ 35/55 ） in the patients with nssopharyngeal DNKSC, being significantly higher in the group surviving less than 5 years 82.1% （32/39） than in the group surviving longer than 5 years 31.6% （6/19） （P 〈 0.05）. Besides, it was closely correlated with the local invasion to the cranial base, there was a significant difference between invasion 74.4% （32/43） and non - invasion 33.3% （4/ 12） （P 〈0.05 ）. A significant difference was found between cranial nerves palsy 77.7% （35/45） and negative groupl0.0% （1/10） （P 〈 0.05）. Conclusion The abnormal expression of c -Met gene expression was well corrlated with the biological behavior of invasion. There exists an important value for the prognosis of nasopharyngeal carcinoma to detect the expression of c - Met.