介入治疗妊娠滋养细胞肿瘤临床疗效及文献复习

Interventional treatment of gestational trophoblastic neoplasia clinical efficacy and review of the literature.

目的探讨动脉灌注栓塞化疗在妊娠滋养细胞肿瘤治疗中的优势。方法对西安市中心医院收治的5例妊娠滋养细胞肿瘤患者的治疗进行回顾性分析及相关的文献复习。结果其中1例绒癌行介入治疗2次,余4例侵蚀性葡萄胎行介入治疗1次;介入治疗后行静脉全身化疗2-3次。所有患者治疗后平均3周转移灶消失,平均2周人绒毛膜促性腺激素(HCG)降至正常。5例患者均临床治愈。随访1.5-2年,HCG值正常,临床无复发。结论动脉灌注栓塞化疗应用于妊娠滋养细胞肿瘤,同时结合静脉化疗及适时的手术,疗效明显,疗程缩短,值得临床推广。

Objective To explore the advantage of the arterial infusion - embolization chemotherapy for gestational trophoblastic neoplasis. Methods Retrospective analysis of the five patients who were treated in Xi＇ an central hospital and the review of the literature. Results One choriocarcinoma was given interventional treatment two times, and the other four invasive mole were given interventional treatment one time, after the interventional treatment, they were given vein - chemotherapy 2 - 3 cycles. The metastasis lesion disappeared 3 weeks later averagely, HCG recovered normally 2 weeks later averagely. All five patients were cured clinically. All the eases had been followed for 1.5 - 2.0 years, the HCG digital was normal, and there＇ s no recurrent cases. Conclusion Giving gestational trophoblastic neoplasis patients arterial infusion - embolization chemotherapy, accompanied with vein - chemotherapy and timely surgery, it can shorten treatment time, and has obviously advantages, so it is worthy of being promoted.