妊高征患者脐动脉S/D与血清NO的相关性

Relations between the umbilical artery S/D and serum nitric oxide of the pregnancy induced hypertension patients

目的探讨妊高征患者脐动脉S/D与血清一氧化氮(NO)的相关性。方法采用Greiss法测定了43例妊高征患者(妊高征组)分娩前外周血血清NO的含量,另选25例正常晚孕妇(正常晚孕组)作对照。应用彩色多普勒超声检测了部分病例子宫动脉及脐动脉血流阻力指标S/D值。结果妊高征组产前外周血血清NO含量均低于正常晚孕组(P<0.01)。妊高征组外周血血清NO含量与脐动脉S/D值呈负相关(r=-0.52,P<0.05)。结论NO的合成减少可能是妊高征发病中的一个重要环节,妊高征患者NO合成减少与胎盘循环阻力增高可能互相影响、互为因果。

Objective To explore the relations between the umbilical artery S/D and serum nitric oxide（NO）in the pregnancy-induced hypertension patients.Methods Serum levels of NO were measured before delivery by Greiss technique in 43 pregnancy-induced hypertension patients（PIH group）and 25 normal late pregnant women（normal pregnant group）.The blood stream resistance index（S/D value）of uterine artery and umbilical artery in some PIH patients were detected by color ultrasonic Doppler.Results The NO levels in prenatal blood serum were lower in PIH group than in normal pregnant group（P0.01）.The serum NO content was negatively correlated to the S/D value of umbilical artery in PIH group（r=-0.52,P0.05）.Conclusion The reduction of NO synthesis might be an important component during the development of PIH.The reduction of NO synthesis in PIH patients and the increase of the placental vascular circulation resistance might influence each other and be reciprocal causation.