不同分型脑外伤患者急性期细胞免疫功能指标变化的观察

Observation on the changes of indexes for cellular immune function in patients with brain injury of different differentiation types at acute period

目的：观察脑外伤分型与细胞免疫功能之间的关系。方法：89例不同分型（根据格拉斯哥昏迷评分，Gcs）脑外伤患者急性期接受了细胞免疫功能指标（cD3、CD4、CD8、CD4／CDs）检测。结果：中、重型脑外伤组（Gcs评分≤12分，34例）患者入院后第1天和第7天cIh、CD4、CD,／CDs浓度均明显低于轻型组（Gcs评分13—15分，55例），两组患者第7天CD3、cD4和中、重型脑外伤组CD4／CD8均明显高于第l天检测结果（P均〈0．01-．05）。结论：中、重型脑外伤患者早期细胞免疫功能受抑制明显。

Objective： To observe the changes of indexes for cellular immune function in patients with brain injury of different differentiation types at acute period. Mellleds： The indexes （CD3, CD4, CDs, CD4/CDs） of cellu/ar immune function were detected in 89 patients with brain injury of different differentiation types [according to Glasgow coma score （GCS）] at acute period. Remdits： The concentrations of CD3 and CD4 and CD4/CDs at the 1st and the 7th days in the patients with cranial injury of the middle to severe brain injury group （GCS≤ 12, n = 34） were obviously lower than those in the mild brain injury group （ 13 ≤ GCS≤ 15, n = 55）. The concentrations of CD3 and CD4 at the 7th day were obviously higher than those at the 1st day in both groups （ P 〈 O. 01 to 0.05）. The CD4/CD8 at the 7th day was obviously higher than that at the 1st day in the middle to severe brain injury group （ P 〈 0.01 to 0.05） Conclusion： The cellular immune function is obviously inhibited in patients with middle to severe brain injury at early period.