新风胶囊对强直性脊柱炎的疗效及焦虑抑郁的影响

Effects of Xinfeng capsule in treating ankylosing spondylitis and dysphoric depression

[目的]观察新风胶囊(XFC)治疗强直性脊柱炎(AS)临床疗效及对焦虑、抑郁情绪的影响。[方法]1)采用焦虑(SAS)、抑郁(SDS)自评量表、疼痛目测类比法(VAS法)、功能指数(BASFI)、疾病活动指数(BASDAI)、整体指数(BAS-G)、症状分级评分等评分。2)将60例AS患者按随机数字表分成治疗组40例,采用XFC,对照组20例采用柳氮磺吡啶(SASP),观察2组的主要症状体征、焦虑、抑郁情绪、血沉(ESR);C-反应蛋白(CRP)等的变化及疗效评价。[结果]临床疗效采用国际强直性脊柱炎评估标准(ASAS20)、BASFI50比较,XFC组分别为75%、70%,SASP组分别为20%、10%,XFC优于SASP(P<0.01或P<0.05);两组组治疗后SAS、SDS积分分别为42.03±8.40、53.80±9.64和41.38±9.16、52.70±6.88,XFC明显优于SASP(P<0.01或P<0.05);其在疼痛评估VAS、症状体征、血沉(ESR)、C-反应蛋白(CRP)、BASDAI、BASFI、BAS-G和BASMI在治疗前后及与SASP组相比,改善明显(P<0.01或P<0.05)。[结论]XFC临床疗效优于SASP,其显著降低SAS、SDS积分;可改善AS患者临床症状及相关指标。

[Objective] To observe the clinical efficacy of Xinfeng capsule （XFC） and the effect on anxiety and depression and ankylosing spondylitis （AS）. [Methods] The grade score was obtained by using anxiety self-rating scale （SAS）, depression self-rating scale（SDS）, pain visual analogue method （VAS method）, functional index （BASF/）, disease activity index （BASDAI）, the overall index （BAS-G）, the symptoms rating scale, etc. Sixty patients of AS were randomly divided into treatment group and control group. Forty patients of treatment group were treated with Xinfeng capsule （XFC）, twenty patients of control group with sulfasalazine （SASP）. The curative effect of main symptoms and signs, anxiety and depression, erythrocyte sedimentation rate（ESR）, C-reactive protein（CRP）, etc. were measured. [Results] The standard criteria of curative effect was ASAS20 and BASDAI50. The curative effect of XFC group was 75%, 70% and that of SASP group was 20%, 10%. The curative effect of XFC group was superior to that of SASP （P〈0.01 or P〈0.05）. The SAS and SDS scores were 42.03±8.40, 53.80±9.64 vs 41.38±9.16, 52.70±6.88 in both groups. The scores of XFC group was superior to that of SASP（P〈0.01 or P〈0.05）. The level of VAS, symptoms and signs, ESR, CRP, BASDAI, BASFI, BAS-G and BASMI in the XFC and SASP group was evaluated. There was a significant difference before and after treatment of XFC and SASP group （P〈0.01 or P〈0.05）. [Conclusion] Clinical effect of XFC group was superior to that of SASP group. It is suggested that XFC may significantly lower SAS, SDS integral, improve clinical symptoms in pa- tients with AS and the related indicators.