110例药品不良反应报告分析

Analysis of 110 cases of adverse drug reaction reports

目的:了解我院药品不良反应(ADR)发生的特点及规律,促进临床合理用药。方法:对我院2006年1月1日～2009年6月30日收集的110例ADR报告分别从患者性别、年龄、给药途径、临床表现、药品种类、不良反应累及系统或器官等进行回顾性分析。结果:引起ADR药物中以抗微生物药物最多,占总数的61.5%。药物引起的不良反应以皮肤过敏反应及胃肠系统表现为多见,分别为28.7%和23.0%。静脉注射给药造成的ADR较多,占总数的88.09%。结论:ADR监测工作任重道远,临床应重视ADR报告和监测工作,加强ADR知识的宣传力度,避免或减少ADR的发生,促进临床合理用药。

Objective：To review the occurrence of adverse drug reactions （ADRs） in our hospital and promote rational drug use in clinic. Methods：110 ADR cases were retrospectively analyzed in respect of the sex of patients,the ages of patients,routes of administration,categories of drugs and systems or organs involved in ADRs. Results：70 categories of drugs were involved in the 110 ADR cases and anti-infective agents ranked the first,accounting for 61.5%. The intravenous drip was the main route of administration,accounting for 88.09%. The lesions of skin and appendants were the main clinical manifestations,accounting for 28.7% and 23.0%. Conclusion：ADR Monitoring is a long way to go,it should be paid more attention to the ADR reports and monitoring in clinic in order to avoid or decrease the occurrence of ADRs. ADR knowledge should be to strengthen advocacy efforts to promote the clinical rational drug use.