重症肌无力伴胸腺瘤患者胸腺组织蛋白4.1R mRNA的表达研究

Expression of protein 4.1R mRNA in patients of thymoma accompanied with myasthenia gravis

目的探讨蛋白4.1R在重症肌无力(myasthenia gravis,MG)伴胸腺瘤患者胸腺组织中的表达情况。方法运用半定量RT-PCR方法检测7例胸腺瘤MG与7例正常对照组胸腺组织中蛋白4.1R的表达。结果胸腺瘤MG组胸腺组织中蛋白4.1R mRNA的相对表达水平为0.84±0.46,与对照组0.43±3.69相比明显增高,差异有统计学意义(P<0.05)。结论蛋白4.1R在胸腺瘤MG患者胸腺组织中mRNA水平表达异常,可能干扰胸腺细胞的信号传导,从而影响胸腺细胞的增殖和活化,参与了MG的发生。

Objective To study the expression of protein 4.1R in the thymus tissues of the patients of thymoma accompanied with myasthenia gravis.Methods The expressions of protein 4.1R mRNA were detected by semi-quantitative reverse transcription polymerase chain reaction（RT-PCR） in 7 thymoma accompanied with MG and 7 normal thymus tissue.Results The relative expressions of protein 4.1R mRNA in the thymoma accompanied with MG（0.84±0.46） were significantly higher than those of control group（0.43±3.69）（P0.05）.Conclusion Protein 4.1R mRNA is expressed abnormally in the thymoma accompanied with MG,which probably impacts the transmission of signal,interferes in the proliferation and activation of thymic cells and participates in the pathogenesis of myasthenia gravis.