奥拉西坦联合高压氧治疗血管性痴呆疗效观察

Observation of curative effect of oxiracetam injection combined with high pressure oxygen treating the vascular dementiame

目的观察奥拉西坦联合高压氧治疗血管性痴呆的临床疗效。方法将150例血管性痴呆患者随机分为3组,分别接受奥拉西坦治疗、高压氧治疗、奥拉西坦和高压氧联合治疗。治疗前后均运用简易智力状态检查量表(MMSE)积分法进行评价。结果3周后奥拉西坦治疗组总有效率82.0%,联合治疗组总有效率90.0%,明显高于高压氧治疗组,各组治疗前后MMSE积分的变化均有显著性差异(P<0.05),而联合用药组总有效率最高,MMSE积分变化最明显,同时不良反应无明显增加。结论奥拉西坦是治疗血管性痴呆的有效药物之一,高压氧治疗对血管性痴呆也有一定效果,两者联合使用能显著改善血管性痴呆患者的MMSE评分,临床疗效确切、安全。

Objective To observe the curative effect of oxiracetam injection combined with high pressure oxygen in the treatment of vascular dementiame.Methods One hundred and fifty cases with vascular dementiame were randomly assigned to 3 groups： oxiracetam injection group,high pressure oxygen group,oxiracetam injection combined with high pressure oxygen group.The MMSE scores were graded before and after treatment.Results After 3 weeks,the total effective rate of oxiracetam injection group and the total effective rate of oxiracetam injection combined with high pressure oxygen group were 82.0% and 90.0%,respectively,which were much higher than the high pressure oxygen group.In each group,the change of the MMSE scores before and after treatment was determined.In the group of treating with oxiracetam injection combined with high pressure oxygen,there was the higher total effective rate and more evident change of the MMSE scores than the other groups,and the side reaction didn＇t increase obviously.Conclusion Oxiracetam injection has effect on the vascular dementiame,while oxiracetam injection combined with high pressure oxygen has the synergistic effect,and the clinical efficacy is definite and safe.