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胃肠道间质瘤分子靶向治疗的不良反应及对策 被引量:17

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摘要 胃肠道间质瘤是胃肠道及腹腔最常见的间叶源性肿瘤。分子靶向治疗被证明对间质瘤疗效显著,但同时也会抑制正常组织细胞运作而产生不良反应。目前已批准应用于间质瘤的分子靶向治疗药物有甲磺酸伊马替尼和苹果酸舒尼替尼,另有尼洛替尼正在临床试验中。此文就胃肠道间质瘤靶向治疗中所出现的各种不良反应的产生机制、临床表现和相应措施作一综述。
作者 王昱 钟捷
出处 《国际消化病杂志》 CAS 2010年第2期93-95,106,共4页 International Journal of Digestive Diseases
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  • 1Roberts PJ, Eisenberg B. Clinical presentation of gastrointestinal stromal tumors and treatment of operable disease. Eur J Cancer, 2002, 38(Suppl 5):S37-S38.
  • 2Demetri GD, von Mehren M, Blanke CD, et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med, 2002, 347: 472-480.
  • 3Esmaeli B, Prieto VG, Butler CE, et al. Severe periorbital edema secondary to STI571 ( Gleevec ). Cancer, 2002, 95: 881-887.
  • 4Scott LC, White JD, Reid R, et al. Managment of skin toxicity related to the use of imatinib mesylate(STI571 ,Glivec^TM) for advanced stage gastrointestinal stromal tumours. Sarcoma, 2005, 9:157-160.
  • 5Verweij J, Casali PG, Zalcberg J, et al. Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: randomized trial. Lancet, 2004, 364: 1127-1134.
  • 6Blanke CD, Rankin C, Demetri GD, et al. Phase III randomized, intergroup trial assessing imatinih mesylate at two dose levels in patients with unreseetable or metastatic gastrointestinal stromal tumors expressing the kit receptor tyrosine kinase: S0033. J Clin Oncol, 2008, 26: 626-632.
  • 7Heinrich MC, Maki R, Corless CL, et al. Sunitinib (SU) response in imatinib-resistant(IM R) GIST correlates with KIT and PDGFRA mutation status. J Clin Oncol, 2006,24:9502.
  • 8Demetri GD, Oosterom AT, Garrett CR, et al. Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial. Lancet, 2006, 368: 1329-1338.
  • 9Sica DA. Angiogenesis inhibitors and hypertension: an emer ging issue. J Clin Oncol, 2006, 24:1329-1331.
  • 10Willett CG, Boucher Y, di Tomaso E, et al. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effectsin human rectal cancer. Nat Med, 2004, 10: 145-147.

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