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MYH相关性息肉病的研究进展 被引量：1

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摘要 MYH基因相关性息肉病(MAP)归属于家族性腺瘤性息肉病(FAP),是一种与MYH基因突变有关的常染色体隐性遗传病。MAP以多发性结直肠腺瘤性息肉和高危险性的结直肠癌为主要临床特点,因此早期诊断和及早防治,对于结直肠癌的早期发现及预防具有重要意义。确诊为MAP的患者可进行外科手术治疗、结肠镜下切除息肉或药物治疗。
作者 程静 王邦茂 王涛
机构地区 天津医科大学总医院消化科
出处 《国际消化病杂志》 CAS 2010年第2期103-106,共4页 International Journal of Digestive Diseases
关键词 MYH基因相关性息肉病 家族性腺瘤性息肉病 MYH基因
分类号 R735.3 [医药卫生—肿瘤] R656.7 [医药卫生—外科学]
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参考文献20

  • 1Durno CA, Gallinger S. Genetic Predisposition to Colorectal Cancer: New Pieces in the Pediatric Puzzle. J Pediatr Gastroenterol Nutr, 2006, 43:5-15.
  • 2Sieber OM, Lipton L, Crabtree M, et al. Multiple colorectal adenomas, classic aclenomatou polyposis, and germ-line mutations in MYH. N Engl J Med, 2003, 348:791-799.
  • 3Al-Tassan N, Chmiel NH. Maynard J, et al. Inherited variants of MYH associated with somatic G: C->T: A mutations in colorectal tumors. Nat Genet, 2002, 30: 227-232.
  • 4郭晓强,杨彩卿.8-oxoG切除修复机制[J].医学分子生物学杂志,2006,3(5):397-400. 被引量：2
  • 5Kim DW, Kim IJ, Kang HC, et al. Germline mutations of the MYH gene in Korean patients with multiple colorectal adenomas. Int J Colorectal Dis, 2007, 22: 1173-1178.
  • 6Miyaki M, Iijima T, Yamaguchi T, et al. Germline mutations of the MYH gene in Japanese patients with multiple colorectaladenomas. Mutat Res, 2005, 578:430-433.
  • 7Lipton L, Halford S, Johnson V, et al. Carcinogenesis in MYH associated polyposis follows a distinct genetic pathway. Cancer Res, 2003, 63:7595-7599.
  • 8Lipton L, Tomlinson I. The multiple colorectal adenoma pheno type and MYH, a base excision repair gene. Clin Gastroenterol Hepatol, 2004, 2: 633-638.
  • 9Middeldorp A, van Puijenbroek M, Nielsen M, et al. High frequency of copy-neutral LOH in MUTYH-associated polyposis carcinomas. J Pathol, 2008, 216: 25-31.
  • 10Cardoso J, Molenaar L, de Menezes RX, et al. Chromosomal instability in MYH and APC-mutant adenomatous polyps. Cancer Res, 2006, 66: 2514-2519.

二级参考文献30

  • 1陈炜,肖卫东,陈祖林,葛海燕.内源性光动力疗法抑制人结肠癌裸鼠种植瘤的实验研究[J].中华实验外科杂志,2004,21(11):1331-1332. 被引量：5
  • 2李军,吕愈敏,顾芳,安燕芳,钱跃清.舒林酸长期治疗家族性腺瘤性息肉病的临床研究[J].中华消化杂志,2005,25(3):153-156. 被引量：16
  • 3[1]CHRISTMANN M,TOMICIC M T,ROOS W P,et al.Mechanisms of human DNA repair:an update[J].Toxicology,2003,193:3-34.
  • 4[2]HAZRA T K,HILL J W,IZUMI T,et al.Multiple DNA glycosylases for repair of 8-oxoguanine and their potential in vivo functions[J].Prog Nucleic Acid Res Mol Biol,2001,68:193-205.
  • 5[3]FROMME J C,BANERJEE A,VERDINE G L.DNA glycosylase recognition and catalysis[J].Curr Opin Struct Biol,2004,14:43-49.
  • 6[4]IDE H,KOTERA M.Human DNA glycosylases involved in the repair of oxidatively damaged DNA[J].Biol Pharm Bull,2004,27:480-485.
  • 7[5]BOITEUX S,GELLON L,GUIBOURT N.Repair of 8-oxoguanine in Saccharomyces cerevisiae:interplay of DNA repair and replication mechanisms[J].Free Radic Biol Med,2002,32:1244-1253.
  • 8[6]TSAI-WU J J,SU H T,WU Y L,et al.Nuclear localization of the human mutY homologue hMYH[J].J Cell Biochem,2000,77:666-677.
  • 9[7]NAKABEPPU Y.Regulation of intracellular localization of human MTH1,OGG1,and MYH proteins for repair of oxidative DNA damage[J].Prog Nucleic Acid Res Mol Biol,2001,68:75-94.
  • 10[8]FROMME J C,BANERJEE A,HUANG S J,et al.Structural basis for removal of adenine mispaired with 8-oxoguanine by MutY adenine DNA glycosylase[J].Nature,2004,427:652-626.

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国际消化病杂志
2010年 第2期

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