依那普利联合硝苯地平治疗原发性高血压疗效观察

Observe the effect of enalapri combined nifedipine in essential hypertension

目的观察依那普利联合硝苯地平治疗原发性高血压的疗效。方法110例原发性高血压患者随机分为治疗组和对照组各55例。对照组给予依那普利治疗,治疗组给予依那普利联合硝苯地平缓释片治疗。治疗4周后评价2组疗效和血压变化情况。结果治疗组显效率52.7%和总有效率92.7%分别高于对照组的36.4%和70.9%,差异均有统计学意义(P<0.05)。2组治疗后收缩压(SBP)、舒张压(DBP)均下降,且治疗组SBP、DBP低于对照组,差异均有统计学意义(P<0.05)。结论依那普利联合硝苯地平治疗原发性高血压效果显著,不良反应少,值得临床推广应用。

Objective To observe the effect of enalapri combine nifedipine in essential hypertension.Methods 110 patients with essential hypertension were randomly divided into treatment group and control group,55 cases of each.The control group were given enalapril;The treated group was treated with enalapril combined nifedipine sustained-release tablets.After 4 weeks of treatment,observed the efficacy evaluation and blood pressure changes of two groups.Results The markedly effective and the total effective rates（52.7% and 92.7%）of treatment group were higher than that of control group（36.4% and 70.9%）,the differences were statistically significant（P0.05）.After treatment,SBP and DBP of the two groups were decreased,the differences were statistically significant（P0.05）.Conclusion The effect of enalapril combined nifedipine in primary hypertension was significant,and adverse reactions was less.