转化生长因子β_1与高血压及其靶器官损害的研究进展

Progress in the relationship on transforming growth factor-β_1 and hypertension and hypertensive target organ injury

原发性高血压病是一种遗传和环境因素综合作用,引起的心血管系统,体液调节功能失调而致的血管平滑肌、心肌及细胞外基质(extracellular matrix,ECM)增生性疾病,常影响重要脏器如心、脑、肾的结构和功能。转化生长因子β1(TGF-β1)是一种调节细胞生长和分化及细胞外基质生成的多功能细胞因子。近来研究表明,TGF-β1及其介导的信号转导在高血压的发生、发展及转归中起着重要作用。现就TGF-β1在高血压及其靶器官的损害中作用的研究进展作一综述。

Hypertension is a proliferative disease of vascular smooth muscle,cardiac muscle and extracellular matrix（ECM） caused by humoral regulation dysfunction of cardiovascular system under the effect of heredity and environment,which does harm to vital organs such as the heart,brain and kidney.TGF-β1 is a kind of multifunction cytokines,stimulates cyto-production,participates in cells proliferation and influences extracellular matrix generation.Evidence illustated that TGF-β1 and its signal transduction play an immportant role in the initiation,progression and turnover of cardiovasculr disease.This review will summarize the progression in research on the role of hypertension and hypertensive target organ injury.