高强度聚焦超声治疗肝癌的疗效观察

High-intensity focused ultrasound in the treatment of liver carcinoma:Therapeutic effect observation

目的探讨高强度聚焦超声(HIFU)对不能手术切除的肝癌患者的疗效、安全性及对肿瘤标志物的影响。方法15例肝癌患者采用平均接受3次高强度聚焦超声(HIFU)治疗,对其进行疗效评价,观察患者的临床受益反应、化学免疫分析法检测CA19-9和AFP浓度。结果15例患者血液检查CA19-9、AFP均有不同程度下降,且有统计学差异(P<0.05或P<0.01)。其中CR3例,PR9例,CR+PR80%,肝脏急性不良反应1级3例,2级1例,无3、4级不良反应。结论高强度聚焦超声能控制肝癌肿瘤进展、改善生活质量、对肿瘤标志CA19-9、AFP有明显下调作用,无明显不良反应。

Objective To investigate the therapeutic effect, safety and the effect of two tumormarkers of high intensity focused ultrasound （HIFU） in treating hepatoma. Methods The 15 patients.suffering from hepatoma were treated with HIFU treatment 3 times in average, and their therapeutic effects were observed, including of clinical benefit response, tumorous objective evaluation, the concentration of several tumor markers to utilize chemoimmunity analytical method for detecting CA19-9） and AFP. Results The the concentration variability of CA19-9, AFP was significant before and after the treatment （P〈0.01 or P〈0.05）. and there were 3 of patients reached CR and 9 reached PR, thus （CR＋PR） was 80%; there were 3 patients with Class I adverse reaction of liver and 1 patient with Class II adverse reaction, there was no patient with Classm or ClasslV. Conclusion HIFU in treating hepatoma can control the progress of tumor, improve the quality of life. It also can reduce CA19-9 and CEA levels. Furthermore, no significant adverse reaction occurres in the treatment.