胰高血糖素样肽2与骨质疏松症的治疗

Glucagon-like peptide 2 and treatment for osteoporosis

胰高血糖素样肽2(glucagon-like peptide 2,GLP-2)是一种多肽类胃肠道生长因子,具有多种生理效应。作为外源性药物,GLP-2可用于治疗骨质疏松症。临床试验结果显示,GLP-2可降低骨吸收,且具有剂量依赖性,但对骨形成没有作用,完整的胃肠道是其发挥作用的必要条件。本文回顾了近年来关于GLP-2的合成、分泌、代谢、GLP-2受体及其介导的信号转导通路的研究进展,以及其用药的安全性和耐受性等问题。

Glucagon-like peptide 2（GLP-2）,as an important gastrointestinal growth factor,has many physiological effects.Exogenous GLP-2 can effectively treat the osteoporosis.The results of clinical trials show that GLP-2 can reduce bone resorption in a dose-dependent manner,but has no effect on bone formation.Integrity of gastrointestinal tract is necessary for its therapeutic effect.This article summarizes the research advances in synthesis,secretion,metabolism and signal transduction of GLP-2 and reviews the safety and tolerability of exogenous GLP-2 in clinical application.