循环应力促进骨折愈合的组织学研究

A HISTOLOGICAL STUDY OF THE EFFECT OF CIRCULATORY STRESS ON FRACTURE HEALING

为探讨循环应力对骨折愈合的组织学影响，应用设定标准的循环应力刺激仪，对86只新西兰大白兔，建立促进挠骨骨折愈合的动物模型。兔自身对侧挠骨作为对照组。定期取大体标本做“三点弯曲应力”等生物力学测定，同时取切片行组织学观察，并在光镜下对骨痂做半定量测定。结果显示：随骨折愈合时间的增加，与对照组相比，实验组中骨小梁成份比例、无机盐沉积量逐渐增大。15天至30天标本，两组间差别有显著意义（P＜0．01）。并与弯曲正应力数值规律相一致。表明循环应力可促进骨母细胞增生、骨痂成熟与改建，有助于骨折愈合。

In order to study the histological effect of circulatory stress, a circulatory stress stimulator with preset criteria is employed in 86 animal models of New Zealand rabbits to test the effect of promotion of the healing of radius fracture. The opposite radii of each animal are used as the controls. Gross specimens are collected on scheduled dates for 'three- point bending stress' and other biomechanical determinations, sections are obtained for histological investigations, and semi - quantitative deter - mination of the callus is carried out under a light microscope. The results show that as compared with the controls, the proportion of bone trabeculae and the quantity of inorganic salt deposits in the experimental radii increased with the time of fracture healing. In the 15 - day and 30 - day specimens, the difference between the two groups is significant(P<0.01), and is in agreement with the numerical rule of positive stress of bending. This shows that circulatory stress promotes the proliferation of osteoblasts, and the maturation and reconstruction of callus, and hence it is helpful to the healing of fracture.