运动、钙和雌激素对去势雌性大鼠股骨生物力学影响的比较

COMPARSION OF FEMORAL BIOMECHANICS INFLUENCED BY EXERCISE, CALCIUM AND ESTROGEN IN OVARIECTOMIZED RATS

目的：了解运动对切除卵巢大鼠前后生物力学改变的影响，并与服钙和雌激素作比较，评价运动在骨质疏松防治中的价值。材料与方法：分组：（1）正常对照组，（2）骨质疏松模型组，（3）运动和服钙联合组，（4）运动-1组：法势后即给予定期运动，（5）运动-2组：去势二月后给予运动，（6）运动对照正常组，（7）制动组，（8）雌激素组和（9）服钙组。检测和分析各组生物力学有关指标（弯曲破坏载荷，强度极限，最大桡度比，弹性系数，韧性系数）。结果：（1）运动各组，服钙组和激素组在除韧性系数外的其他指标与正常组无显著性差异；（2）联合组各项指标与正常组无显著性差异；（3）运动各组之间的各项指标无显著性差异；（4）激素组韧性系数小，显示其欠佳的生物力学性能；（5）制动组的各项指标与各运动实验组有显著性差异。结论：运动对改善大鼠生长期和去势后早期以及中期生物力学性能有一定作用，本实验为下一步设计合理运动方案防治骨质疏松提供实验依据。

Objectives:To assess and compare the influence of exercise, calcium and estrogen on biomechanics of femurs in ovariectomized rats. Material and Method: Nine groups were established: (1)Normal Control group;(2)Osteoporosis model(OVX), (3)Combined Exercise and Calcium (Ex-Ca group); (4)Exercise-1 group;(5)Exercise-2 group;(6)Exercise Control Normal group (Ex-C), (7)Immobilization group (I group), (8)Female Hormone group (H group) and (9)Calcium group. Parameters of biomechanics were measured and analyzed. Results:The result of biomechanic tests showed that:(1)No significant difference was observed in all parameters except Flexibility Coefficient between Normal Control group and all groups related to exercise, calcium and estrogen. (2)No significant difference was obtained between E-Ca group and Normal group in all parameters. (3)No significant difference was showh among all 4 groups related to Exercise in all parameters. (4)biomechanic test showed that Flexibility in H-group was worse than in Normal group, indicating that the biomechanic charaters in H group were not good as those in exercise groups. (5)There was significantly difference between I-group and all exercise groups in each parameter. Concludsion:Exercise was showed to be independent effects for improving biomechanic nature during the growing stage and early and middle stage after ovarietomy, providing valuable information for designing rational exercise scheme to prevent postmenopausal osteoporosis.