藏药戟叶垂头菊中三萜类成分的分离和结构鉴定

Isolation and structural elucidation of triterpenes from Cremanthodium potaninii C. Winkl

目的:对来自青海省的藏药戟叶垂头菊(Cremanthodium potaninii C.Winkl)花序化学成分进行分离鉴定。方法:利用普通硅胶柱色谱方法和制备薄层色谱等方法进行分离、纯化,并经超导核磁共振(NMR)、质谱(MS)、红外(IR)等现代波谱技术确定其结构。结果:从戟叶垂头菊的乙醇提取物中获得7个三萜类化合物,主要运用超导核磁共振(NMR)技术,结合文献中已报道的波谱数据等,确定了它们的结构分别为:α-香树脂醇(Ⅰ)、棕榈酸16β-羟基蒲公英甾醇酯(Ⅱ)、olean-12-en-3β,16β-diol-3-O-palmitate(Ⅲ)、olean-12-en-3β,11α,16β-triol-3-O-palmitate(Ⅳ)、棕榈酸16β-羟基羽扇醇酯(Ⅴ)、棕榈酸16β,28-二羟基羽扇醇酯(Ⅵ)、16β-羟基假蒲公英甾醇酯(Ⅶ)。结论:这7个化合物均为首次从该植物中分离得到。

AIM： To isolate and identify triterpenes from inflorescence of Cremanthodium potaninii C.Winkl,collected from Qinghai province.METHODS： The triterpenes were isolated by column chromatography and their structures were elucidated through NMR.RESULTS： Seven triterpenes were isolated and identified as α-amyrin（I）,Taraxast-20（30）-ene-3β,16β-diol-3-O-palmitate（II）,olean-12-en-3β,16β-diol-3-O-palmitate（III）,Olean-12-en-3β,11α,16β-triol-3-palmitate（IV）,lup-3β,16β-diol-3-O-palmitate（V）,lup-3β,16β,28-triol-3-O-palmitate（VI）,16β-hydroxypseudo tarsxasterol-3-O-palmitate（VII）.CONCLUSION： All these compounds are obtained from Cremanthodium potaninii C.Winkl for the first time.