烟酰胺磷酸核糖转移酶与妇产科疾病

Nicotinamide Phosphoribosyl Transferase and Gynaecology and Obstetrics

烟酰胺磷酸核糖转移酶(Nampt)是一种结构高度保守的细胞因子,在最初克隆后近十年中Nampt并未引起关注。自2005年后,越来越多的研究发现,Nampt具有很多功能,其不仅是一种能模拟胰岛素作用的肽类激素,还是一种具有多种生物效应的脂肪因子。Nampt还具有酶的活性,参与细胞多种功能的调控,并与人类多种疾病和病理状态的发生有密切的关系,因而引起高度关注。就Nampt的特点及其与妇产科疾病的关系综述。

Nicotinamide phosphoribosyltransferase（Nampt） is a cytokine with highly conserved structure.It received little notice during the first ten years.However,since 2005,Nampt has garnered an increasing attention due to accumulating evidence indicating that Nampt is a pleiotropic protein like peptide hormone,adipocytokine and nicotinamide phosphoribosyltransferase.Nampt is not only involved in regulating of cell multiple functions,but also implicated in the pathogenesis of a number of human diseases and conditions.This review will cover the current progress of the associations among Nampt and gynecologic and obstetric diseases or conditions.