子宫颈小细胞癌研究进展

Advances of the Study for Small Cell Carcinoma of the Cervix

宫颈小细胞癌(SCCC)属神经内分泌癌,是一种高度恶性的妇科肿瘤。因恶性度高、进展快、复发率高,早期即可有淋巴结转移及血行播散,故预后差。其诊断以组织病理形态学为基础,联合免疫组织化学标记以提高诊断的准确率,治疗以手术辅以放疗、化疗综合治疗为主。近年对宫颈小细胞癌的研究以个案和小宗病例报道为主,就其临床病理特点及诊断治疗方法等综述。旨在提高宫颈小细胞癌的诊断率,改善患者的治疗及预后。

Small cell carcinoma of the cervix is a rare and highly malignant neuroendocrine tumor.Because of its rapid progression,high recurrence rate,lymphonode and hematogenous dissemination in early stage,its prognosis is poor.Diagnosis of SCCC is based on pathomorphology,combing with immunohistochemistry biomarkers can improve its diagnosis.Operation combined with radiotherapy and chemotherapy is recommended to be the main therapy of SCCC.Recently,the reports of SCCC are usually about individual cases or small number of cases.To improve the diagnosis and prognosis,we review its clinical characteristics and advances in both diagnosis and treatment.