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乙型肝炎病毒前S1抗原检测的临床应用 被引量:3

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摘要 目的:探讨乙肝前S1抗原(Pre S1-Ag)与乙肝病毒DNA(HBV-DNA)及乙肝病毒e抗原(HBeAg)之间的关系。方法:用酶联免疫吸附试验(ELISA)测定200例HBsAg阳性乙肝患者的pre S1-Ag和HBeAg,定量PCR法检测其HBV-DNA。结果:Pre S1-Ag与HBV-DNA和HBeAg正相关(P<0.05)。在HBV-DNA阳性患者中,尤其在HBV-DNA低于5×104copy/ml的低水平组中,Pre S1-Ag的检出率显著高于HBeAg(P<0.05)。结论:Pre S1-Ag能比HBeAg更敏感地反映出HBV的传染性和复制情况。
机构地区 丽水市中心医院
出处 《中国高等医学教育》 2010年第4期136-137,共2页 China Higher Medical Education
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