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PC-1与胰岛素抵抗和阻塞性睡眠呼吸暂停低通气综合征的关系

The association of obstructive sleep apnea hypopnea syndrome with PC-1 and insulin resistance
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摘要 阻塞性睡眠呼吸暂停低通气综合征（obstructive sleep apnea hypopnea syndrome，OSAHS）是一种涉及多种基因、环境因素、生长因素的复杂疾病。本文通过探讨浆细胞膜糖蛋白-1（Plasma cell membrane glycoprotein-1，PC-1）与胰岛素抵抗（Insulin resistance，IR）、OSAHS与肥胖、OSAHS的遗传分子水平研究进展、OSAHS与IR、PC-1及其基因多态与OSAHS相互间的关系，得出在控制OSAHS中IR是关键因素，而PC-1及其基因多态性的研究为IR及与其相关的OSAHS危险因素的预测和防治提供了一种新思路。希望在不久的将来可以确定OSAHS的遗传模式，并找到具体遗传物质，为其基因水平的治疗奠定基础。 Obstructive sleep apnea hypopnea syndrome （OSAHS） is a complex disease relating to multiple genes, environmental influences and developmental factors. This article discussed the relationship between Plasma cell membrane glycoprotein-1 （PC-1） and Insulin resistance （IR）, OSAHS and Obesity, the research of genetic molecular level about OSAHS, OSAHS and IR, PC-1 and its polymorphism. It concluded that IR was the key factor in controlling OSAHS. The study of PC-1 and its polymorphism offers a new idea in forecasting and preventing the related risk factors of OSAHS and IR. Hope we may make certain about the genetic mode of OSAHS in the future, and find the material germ plasm, to establish foundation in treating OSAHS at genetic level.
作者 顾美珍（综述） 张伟（审校） 陈春娟（审校）
机构地区 上海市闸北区市北医院耳鼻咽喉科
出处 《世界感染杂志》 2010年第1期56-59,71,共5页 World Journal of Infection
关键词 胰岛素抵抗 浆细胞膜糖蛋白-1 阻塞性睡眠呼吸暂停低通气综合征 Insulin resistance （IR） Plasma cell membrane glycoprotein-1 （PC-l） Obstructive sleep apnea hypopnea syndrome （OSAHS）
分类号 R765.041 [医药卫生—耳鼻咽喉科]
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参考文献28

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二级参考文献13

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世界感染杂志
2010年 第1期

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