维吾尔族青光眼OCT3检测RNFL厚度与视野缺损的相关性研究

Correlation between the thickness of RNFL detected by OCT3 and visual field defect in Uygur patients with glaucoma

目的:研究OCT3检测青光眼视网膜神经纤维层厚度与Humphrey750型视野计检测视野缺损的相关性。方法:维吾尔族青光眼47例79眼,汉族青光眼对照组21例38眼,维吾尔族正常对照组15例30眼,分别对各组进行OCT3和视野检测,比较各组指标差异,并进行视网膜神经纤维层厚度与视野相关性分析以及维族青光眼组分层分析。结果:维族青光眼组与维族正常组间的比较结果为两组的OCT1∶00,11∶00及上象限、全自动视野的MD和PSD差异具有极显著性(P<0.01),OCT6∶00,7∶00,12∶00和下象限差异具有显著性(P<0.05),维族青光眼组与汉族青光眼组间的OCT参数差异没有显著性。维族青光眼组OCT指标与视野指标相关且随着青光眼分期相关性加强。结论:OCT在青光眼的诊断中有较好的诊断价值,OCT在青光眼的视网膜神经纤维层厚度检测与视野相关,OCT检测能够验证视野的检测,为青光眼的诊断提供了量化标准。

AIM： To study correlation between the thickness of retinal nerve fibre layer（RNFL）detected by OCT3 and visual field defect in Uygur patients with glaucoma. METHODS： Uygur patients with glaucoma 47 cases（79 eyes）, Han nationality patients with glaucoma 21 cases （38 eyes）, and Uygur normal people 15 cases （30 eyes） were included. The differences of OCT3 and visual field between Uygur patients and Uygur normal and between Uygur patients and Han nationality patients were compar-ed. The correlation between RNFL thickness and visual field defect was analyzed through Uygur patients. RESULTS： OCT 1 ∶00, 6 ∶00, 7 ∶00, 11 ∶00, 12 ∶00 the mean defect and pattern standard deviation in the superotemporal quadrant and visual field showed signifi-cant difference between Uygur patients and Uygur normal. Of OCT parameters, there was no significant difference between Uygur patients and Han nationality patients. The correlation in Uygur patients between OCT and visual field defect was stronger along with stage of glaucoma. CONCLUSION： OCT had better diagnostic value in glaucoma,RNFL and visual field defect is correlated.OCT can verify visual field. Such OCT offers measure target for glaucoma.