脓毒症患者血清胆碱酯酶变化及其临床意义

Serum Cholinesterase and Its Clinical Significance in Patients with Sepsis

目的:探讨脓毒症患者血清胆碱酯酶(cholinesterase,ChE)变化及其临床意义。方法:检测患者血清ChE浓度,并进行急性生理学与慢性健康状况(APACHE)Ⅱ评分。根据是否发生脓毒血症将患者分为脓毒症组和对照组,其中脓毒症患者分为死亡组和存活组,了解组间血清ChE水平变化及其对病情和预后的影响。结果:(1)脓毒症患者血清ChE水平低于对照组患者(P<0.01)。(2)脓毒症患者死亡组血清ChE水平明显低于存活组(P<0.05)。(3)脓毒症患者血清ChE水平与其APACHEⅡ评分呈负相关(r=-0.280,P<0.05),与血清白蛋白和体质量指数呈正相关(r分别为0.458和0.287,P<0.05)。结论:血清ChE水平可用于判断脓毒症患者病情严重程度及预后。

Objective：To explore the changes of serum cholinesterase （ChE） and its clinical significance in patients with sepsis. Methods：Serum cholinesterase concentration, acute physiology and chronic health evaluation （APACHE） Ⅱscores were estimated in patients. The patients in this study were divided into the sepsis group and the non-sepsis group. The patients with sepsis were further divided into the death group and the survival group. The influence of altered serum ChE levels on prognosis was compared between the groups. Results：（1） Serum ChE was significantly lower in patients of sepsis group than that of control group （P 0.01）. （2） In patients with sepsis, the serum ChE level was significantly lower in the death group compared with that of survival group （P 0.05）. （3） In patients with sepsis the serum ChE levels were significantly negatively correlated with APACHE Ⅱ scores （r = -0.280, P 0.05）, positively correlated with serum albumin and body mass index （r = 0.458 and 0.287,P 0.05）. Conclusion： Serum ChE levels can be used to determine the prognosis and severity of illness in patients with sepsis.