希罗达联合周剂量奥沙利铂治疗老年晚期胃癌的疗效

Afficacy of xeloda combined with weekly dosage of oxaliplatin in the treatment of advanced gastric cancer in the elderly

目的评价希罗达联合周剂量奥沙利铂治疗老年晚期胃癌的近期疗效及毒副反应。方法初治组12例,复治组8例。患者给予希罗达1000 mg/m2,饭后半小时口服,2次/d,第1～14天;静脉滴注奥沙利铂65 mg/m2,每周1次,连用2周,每3周重复。2个周期化疗后进行疗效和不良反应评估。结果全组20例,治疗总有效率为45.0%。初治组有效率为50%,复治组有效率为37.5%。主要不良反应为Ⅰ、Ⅱ度白细胞下降和消化道反应;少数患者出现Ⅰ～Ⅱ度周围神经毒性。结论希罗达联合周剂量奥沙利铂治疗老年晚期胃癌疗效显著,耐受性良好。

Objective To study the afficacy and side effects of the xeloda combined with weekly dose of oxaliplatin in the treatment of advanced gastric cancer in elder patients.Methods Twenty patients aged 65 to 84 years old with advanced gastric cancer received oral xeloda 1000 mg/m2,bid,D 1-14 and intravenous oxaliplatin 65 mg/m2 ones an week for two weeks.Three weeks were taken as one cycle of treatment.The efficacy and side effetcts were evaluated after 2 cycles of treatment.ResultsThe overall effective rate was 45.0%.The effective rats were 50% in the patients for primary treatment and 37.5% for those had been treated with other chemotherapy.The major side effects were decrease of white blood cell （grade Ⅰ-Ⅱ） and gastrointestinal response.Peripheral neuropathy toxicity（grade Ⅰ-Ⅱ） was seen in some cases.Conclusion Xeloda combined with weekly dose of oxaliplatin is effective in the elder patients with advanced gastric cancer with tolerable side effects.