丹参联合厄贝沙坦治疗早期慢性肾衰的疗效

Efficacy of salvia miltiorrhiza combined with irbesartan in treating chronic renal failure in early stage

目的探讨丹参对早期慢性肾功能衰竭(CRF)患者的肾保护作用。方法63例CRF患者随机分为对照组(31例)和治疗组(32例),对照组用厄贝沙坦治疗,治疗组用丹参+厄贝沙坦洽疗,疗程均为6个月。检测并比较治疗前后的血尿素氮(BUN)、血清肌酐(Cr)、总胆固醇(TC),甘油三酯(TG)和尿蛋白。结果两组患者的肾功能、尿蛋白和血脂均有明显改善,治疗组明显优于对照组。结论丹参能够有效的降低CRF患者的尿蛋白水平,改善血脂代谢紊乱。

Objective To investigate the efficacy of salvia miltiorrhiza combined with irbesartan in the patients with chronic renal failure（CRF） in early stage.Methods Sixty-three patients with CRF in the early stage were randomly divided into two groups.The patients in therapeutic group（32 cases） were treated with salvia miltiorrhiza combined with irbesartan,and those in control group（31 cases） with irbesartan alone.The therapeutic course of both groups was six months.Blood urea nitrogen（BUN）,serum creatinine（SCr） and triglyceride（TG） and proteinuria were examined and compared before and after treatment.Results Compared with thos before,BUN,SCr,cholesterol（TC）,TG and proteinuria were improved significantly after treatment in both groups,which were lower in therapeutic group than those in control group.Conclusion Salvia miltiorrhiza may decrease proteinuria and improve lipometabolism in the patients with CRF in early stage.