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γH2AX和ATM与内源性氧化剂所致DNA损伤关系的研究进展 被引量：2

Progress in the research of relationship between γH2AX,ATM and DNA damage by endogenous oxidants
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摘要 本文综述了正常细胞及肿瘤细胞系中内源性氧化剂所致的磷酸化ATM(CAA)和γH2AX(CHP)的形成与表达;同时综述了各种影响因子和生长条件对CAA和CHP表达的影响。 This review describes the observations that constitutive ATM activation（CAA） and H2AX phosphorylation（CHP） caused by endogenous oxidants in normal cells as well in tumor cell lines.This review also reported the findings on differences in CAA and CHP on the effects of several agents and growth conditions.
作者 赵晋 郭忠 马建秀
机构地区 西北民族大学医学院
出处 《基础医学与临床》 CSCD 北大核心 2010年第4期437-441,共5页 Basic and Clinical Medicine
基金 西北民族大学中青年科研基金项目(XBMU-2008-BD-96)
关键词 内源性氧化剂 γH2AX ATM endogenous oxidants γH2AX ATM
分类号 R362 [医药卫生—病理学] R730.2 [医药卫生—肿瘤]
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参考文献22

  • 1Bonner WM, Redon CE, Dickey JS, et al. GammaH2AX and cancer [ J ]. Nat Rev Cancer,2008,8 (12) :957 - 967.
  • 2Hakem R. DNA-damage repair; the good, the bad, and the ugly [ J ]. EMBO J ,200S ,27 (4) :589 - 605.
  • 3Jeggo PA, Lobrich M. DNA double-strand breaks: their cellular and clinical impact? [ J]. Oncogene, 2007, 26 (56) :7717 -7719.
  • 4Bartova E, Krejci J, Harnicarova A, et al. Histone modifications and uclear architecture: a review [ J ]. J Histochem Cytochem,2008,56 (8) : 711 - 721.
  • 5Ismail IH, Wadhra TI, Hammarsten O. An optimized method for detecting γ-H2AX in blood cells reveals a significant interindividual variation in the γ-H2AX response among humans [J]. Nucleic Acids Res,2007,35(5) :e36.
  • 6Fragkos M, Jurvansuu J, Beard P. H2AX is required for cell cycle arrest via the P53/p21 pathway [ J ]. Mol Cell Biol,2009,29 (10) :2828 - 2840.
  • 7Banath JP, Banuelos CA, Klokov D, et al. Explanation for excessive DNA single-strand breaks and endogenous repair foci in pluripotent mouse embryonic stem cells [ J ]. Exp Cell Res, 2009,315 ( 8 ): 1505 - 1520.
  • 8Chowdhury D, Xu XZ, Zhong XY, et al. A PP4-phosphatase complex dephosphorylates γH2AX generated during DNA replication [ J ]. Mol Cell,2008,31 ( 1 ) :33 - 46.
  • 9Nakada S, Chen GI, Gingras AC, et al. PP4 is a γH2AX phosphatase required for recovery from the DNA damage checkpoint [J]. EMBO Rep,2008,9(10) : 1019 - 1026.
  • 10Nakamura A J, Chiang YJ, Hathcock KS, et al. Both telomerie and non-telomeric DNA damage are determinants of mammalian cellular senescence [ J ]. Epigenet Chromatin, 2008,1(1) :6.

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基础医学与临床
2010年 第4期

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