摘要
目的:阐明白介素-18(IL-18)与缺血性脑卒中(IS)的相关性。方法:采用病例对照研究方法,对IS病例组423例和对照组384名(两组研究对象年龄、性别匹配,均为中国汉族人群)应用聚合酶链反应技术(PCR)及凝胶电泳技术进行IL-18基因启动子-607 C/A(rs1946518)分析。用Logistic回归分析去除混杂因素的影响,分析其基因型、等位基因型与缺血性脑卒中发病的相关性。结果:-607C等位基因型与IS发病有相关性,是IS重要的危险因素(OR=1.358,P=0.002)。结论:中国汉族人群中,IL-18基因启动子的多态性可能与IS的发病有关,等位基因型-607C可能增加IS的发病风险。
Aim： To elucidate the role of IL-18 as a potential cause of ischemic stroke （IS） susceptibility in Chinese partial Han population. Methods： A case-control study was taken from 423 IS patients and 384 healthy controls matched for age and sex. The functional polymorphisms of -607C/A （rs1946518） in IL-18 promoter were analyzed by using polymerase chain reaction （PCR） and agarose gel electrophoresis. The association of the genotype and allele frequencies with the risk of ischemic stroke was elucidated. Logistic regression was used to adjust for confounding variables. Results： -607C allele was associated with an increased risk of IS （odds ratios/OR=l.358, P=0.002）. Conclution： The results suggested that the functional polymorphisms in IL-18 promoter may be involved in the risk of developing IS in Chinese partial Hart population.
出处
《中国临床神经科学》
2010年第2期146-151,共6页
Chinese Journal of Clinical Neurosciences
