阴茎海绵体平滑肌细胞表型转化及其影响因子的研究进展

Phenotypic modulation of corpus cavernous smooth muscle cells and its influencing factors

阴茎海绵体平滑肌细胞是组成阴茎海绵体的主要功能成分,其表型转化是平滑肌细胞增殖和迁移的关键性起始步骤。因此,探讨平滑肌细胞表型转化的机制及其影响因子在阴茎勃起功能障碍的防治过程中具有重要意义。目前通常将平滑肌细胞分为收缩型(分化型)和合成型(未分化型、增殖型或去分化型)两种类型,并发现L转化生长因子(TGF-β)、转录因子E2F1、基本转录元件结合蛋白2(BTEB2)、胰岛素等因素可能影响平滑肌细胞表型转化。本文就近年来阴茎海绵体平滑肌细胞表型转化及其影响因子的研究进展作一简要综述。

Corpus cavernous smooth muscle cells are the main functional component of the corpus cavernosum penis,whose phenotypic modulation is the key initial step in the proliferation and migration of smooth muscle cells.Therefore,an insight into the mechanism of the phenotypic modulation of smooth muscle cells and its influencing factors is important for the prevention and management of penis erectile dysfunction.Smooth muscle cells are generally divided into contracting（differentiated）and composing（undifferentiated,proliferated or dedifferentiated）types.It is found that TGF-β,transcription factor E2F1,BTEB2 and insulin may affect the phenotypic modulation of smooth muscle cells.This paper presents an overview of the progress in the researches on the phenotypic modulation of corpus cavernous smooth muscle cells and its influencing factors.