摘要
心肌缺血再灌注损伤(myocardial ischemia-reperfusion injury,MI/RI)的形成是一个复杂的变化过程,其中血小板、中性粒细胞和血管内皮细胞三者是MI/RI发生的主要参与者,而P-选择素在这三者之间的调控中发挥了重要的介导作用。本文就P-选择素在MI/RI发生过程中对这几种物质所产生的介导作用作一综述。
The process of myocardial ischemia-reperfusion injury （MI/RI） is complex and dynamic. Platelets,neutrophils and vascular endo- thelial cells are three key players in MI/RI, and P selectin plays an important role in the transductive regulation among these players. This review summarizes the mediation of P-selectin among several kinds of materiaes in the process of MI/RI.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2010年第2期238-240,共3页
Chinese Journal of Clinical Pharmacology and Therapeutics
关键词
P-选择素
心肌缺血再灌注损伤
血小板内皮细胞
中性粒细胞
P-selectin
Myocardial ischemia-reperfusion injury
Platelets
Neutrophils
Vascular endothelial cells
