期刊文献+

慢性阻塞性肺疾病急性加重期患者的血浆生物标志物变化 被引量:7

原文传递
导出
摘要 COPD是目前全球致残和致死率较高的疾病之一。COPD急性加重(AECOPD)与肺功能加速减损、生命质量降低及病死率增高密切相关。AECOPD导致患者反复住院,并构成疾病费用的主要部分。然而,AECOPD及其严重程度的定义缺乏客观指标,主要依据患者的主观症状和医生的判断。因此,有必要寻找一种或多种简便易测的血浆生物标志物,以提供AECOPD的客观证据。理想的生物标志物不仅有助于区分COPD稳定期与AECOPD,还可预示病情的严重程度。
作者 崔德健
出处 《中华结核和呼吸杂志》 CAS CSCD 北大核心 2010年第4期295-297,共3页 Chinese Journal of Tuberculosis and Respiratory Diseases
  • 相关文献

参考文献27

  • 1Kidney J,McManus T,Coyle PV.Exacerbations of chronic obstructive pulmonary disease.Thorax,2002,57:753-754.
  • 2Sullivan SD,Ramsey SD,Lee TA.The economic burden of COPD.Chest,2000,117(2 Suppl):5S-9S.
  • 3Rabe KF,Hurd S,Anzueto A,et al.Global strategy for the diagnosis,management,and prevention of chronic obstructive pulmonary disease;GOLD executive summary.Am J Respir Crit Care Med,2007,176:532-555.
  • 4Stolz D,Stulz A,Müller B,et al.BAL neutrophils,serum procalcitonin,and C-reactive protein to predict bacterial infection in the immunocompromised host.Chest,2007,132:504-5l4.
  • 5张庚,陈扬波,余丹凤,胡马洪.脓毒症患者急性时相蛋白的动态联合检测[J].中国危重病急救医学,2005,17(4):223-227. 被引量:11
  • 6Hurst JR,Donaldson GC,Perera WR,et al.Use of plasma biomarkers at exacerbation of chronic obstructive pulmonary disease.Am J Respir Crit Care Med,2006,174:867-874.
  • 7Bozinovski S,Hutchinson A,Thompson M,et al.Serum amyloid a is a biomarker of acute exacerbations of chronic obstructive pulmonary disease.Am J Respir Crit Care Med,2008,177:269-278.
  • 8Steel DM,Donoghue FC,O' Neill RM,et al.Expression and regulation of constitutive and acute phase serum amyloid A mRNAs in hepatic and non-hepatic cell lines.Scand J Immunol,1996,44:493-500.
  • 9Sha Q,Truong-Tran AQ,Plitt JR,et al.Activation of airway epithelial cells by toll-like receptor agonists.Am J Respir Cell Mol Biol,2004,31:358-364.
  • 10Meng QR,Gideon KM,Harbo SJ,et al.Gene expression profiling in lung tissue from mice exposed to cigarette smoke,lipopolysaccharide,or smoke plus lipopolysaccharide inhalation.Inhal Toxicol,2006,18:555-568.

二级参考文献51

共引文献61

同被引文献101

  • 1柳涛,蔡柏蔷.一种新型的生活质量评估问卷:慢性阻塞性肺疾病评估测试[J].中国医学科学院学报,2010,32(2):234-238. 被引量:161
  • 2尤勇.老年慢性支气管炎患者急性发作期血清肿瘤坏死因子-α、白细胞介素-6含量变化及对预后的影响[J].中国老年学杂志,2014,34(3):680-681. 被引量:27
  • 3中华人民共和国卫生部.WS 318-2010慢性阻塞性肺疾病诊断标准.北京:中国标准出版社,2010.
  • 4Karayama M,Inui N,Suda T,et al.Antiendothelial cell antibodies in patients with COPD.Chest,2010,138:1303-1308.
  • 5Han MK,Agusti A,Calverley PM.et al.Chronic obstructive pulmonary disease phenotypes:the future of COPD.Am J Respir Crit Care Med,2010,182:598-604.
  • 6Burgel PR,Paillasseur JL,Caillaud D,et al.Clinical COPD phenotypes:a novel approach using principal component and cluster analyses.Eur Respir J,2010,36:531-539.
  • 7Guntupalli KK,Gutterman D,Raoof S,et al.2010:the year of the lung.Chest 2010,138:1287-1288.
  • 8Brito-Mutunayagam R,Appleton SL,Wilson DH,et al.GlobalInitiative for Chronic Obstructive Lung Disease stage 0 is associated with excess FEV (1) decline in a representative population sample.Chest,2010,138:605-613.
  • 9张富强 郑劲平 王佳泓 等.支气管舒张试验的容量和流量反应评估慢性阻塞性肺疾病比较[J].中华结核和呼吸杂志,2010,.
  • 10Hannink JD,van Helvoort HA,Dekhuijzen PN,et al.Dynamic hyperinflation during daily activities.Does COPD Global Initiative for Chronic Obstructive Lung Disease stage matter? Chest,2010,137:1116-1121.

引证文献7

二级引证文献149

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部