红斑狼疮患者外周血内皮祖细胞数量与颈动脉内膜-中膜厚度相关性研究

The correlation between peripheral endothelial progenitor cells levels and the intima-mediathickness of carotid artery in patients with systemic lupus erythematosus

目的探讨系统性红斑狼疮(SLE)患者外周血内皮祖细胞(EPC)与颈动脉内膜-中膜厚度(IMT)的关系。方法连续选入40例SLE患者做为SLE组,超声检测颈动脉IMT按IMT增厚与否分为IMT正常组和IMT增厚组,20名门诊健康体检者为对照组。流式细胞分析计量外周血EPC(CD34和KDR双阳性细胞);比较各组EPC数量及直线相关分析EPC数量和IMT相关性。结果SLE组外周血EPC数量较对照组显著减少,P<0.01;同时在SLE组中IMT增厚组EPC数量低于IMT正常组,P<0.01,且IMT与外周血EPC数量呈负相关(n=40,r=-0.494,P=0.006)。结论SLE患者存在早期动脉粥样硬化,外周血EPC数量降低与颈动脉IMT增加密切相关,外周血EPC数量降低可能是SLE引起早期动脉粥样硬化的重要原因之一。

Objective To investigate the correlation between peripheral endothelial progenitor cells（EPC） levels and the intima-media thickness（IMT） of carotid artery in patients with systemic lupus erythematosus（SLE）.Methods Peripheral EPC was enumerated as CD34＋/KDR＋cell via fluorescence-activated cell sorter analysis,and the IMT of carotid artery was measured,respectively in 40 SLE patients and 20 controls.The patients with SLE were divided into two subgroups according to IMT≥1.0 mm and IMT〈1.0 mm.Results The number of EPC was decreased in SLE,P0.01.In addition,The number of EPC in the IMT≥1.0 mm subgroup was observed lower than that in the IMT〈1.0 mm subgroup,P0.01,the number of EPC was negatively related to the IMT in patients with SLE（r=-0.494,P=0.006）.Conclusions Premature atherosclerosis exists in SLE patients,there is a correlation between peripheral EPC level and the IMT of carotid artery.The decrease of EPC may be an important factor of the SLE induced atherosclerosis.