期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

糖皮质激素的非基因组作用及机制 被引量：1

糖皮质激素的非基因组作用及机制
下载PDF
导出
摘要 糖皮质激素是调节机体代谢的重要激素,糖皮质激素的作用有经典的基因组作用和快速的非基因组作用。本文旨在探讨近年来有关糖皮质激素非基因组作用及其可能的分子机制的研究进展。 Glucocorticoid play an important role in regulating metabolism. It has the both classic genomic effects and rapid non-genomie effects. We intend to explore the non-genomic effects and possible molecular mechanism of glucocorticoid in recent years.
作者 韩坤 王倩梅
机构地区 漯河医学高等专科学校生理教研室
出处 《当代医学》 2010年第6期18-19,共2页 Contemporary Medicine
关键词 糖皮质激素 非基因组作用 糖代谢 Glucoeorticoid Non-genomic effect Glucose metabolism
分类号 R96 [医药卫生—药理学]
  • 相关文献

参考文献11

  • 1Simoncini T,Andera RG.Non-genomic actions of sex steroid hormones[J]. European Journal of Endocrinology, 2003, 148(3): 281 -292.
  • 2Losel RM,Falkenstein E,Feuring M,et al.Nogenomic steroid action: controversies, questions, and answers[J]. Physiol Rev, 2003 ,83(3): 965-1016.
  • 3RAY PD,Foster DO,Iardy HA.mode of action of glucocorticoids. I.stimulation of luconeogenesis independent of synthesis denovo of enzymes[J].J boil Chem, 1964,239.3396-3400.
  • 4Sistare FD,Haynes R,C Jr. Acute stimulation by glucocorticoids of giuconeogenesis from lactate/pyruvate in isolated hepatocytes from normal and adrenalectomized rats[J]. J Biol Chem, 1985,260(23): 12754-12760.
  • 5Sun HW,Miao CY,Liu L,et al.Rapid inhibitory effect of glucocorticoids on airwaysmooth muscle contraction in guinea pigs[J]. Steroids 2006,71(2):154-159.
  • 6Losel R,Wehling M. Nongenomic actions of streoid hormones[J].Nat Rev Mol Cell Biol,2003,4(1).46-56.
  • 7Koukouritaki SB,theodoropoulous PA,Margioirs AN,et al.Dexamethasone alters rapidly action polymerization dynamics inhuman endometrial cells:envidence for nongenomic actions involving cAMP turnover[J].J Cell Biochem, 1996,62(2):251-261.
  • 8Gamotchu 6.Glucocorticoid receptor-like antigen in lymphoma cell membranes:correlation to cell lyeis[J].Science,1987,236(4600):456-461.
  • 9Gametchu B,Wateon CS,Wu S.Use of receptor antibodies to demonstrate membrane glucocorticoid receptor in cells from human leukemic patients[J].FASEB J,1993,7(13):1283-1292.
  • 10Iowenberg M,tuynman J,bilderbeek J,et al.Rapid immunosupressive effects of glucocorticoids mediated through lck and fyn[J].Blood,2005,106(5):1703-1710.

同被引文献10

  • 1Alexander JK, DeVries AC, Kigerl KA, et al. Stress exacer- bates neuropathic pain via glueocortieoid and NMDA receptor activation. Brain Behav Immun, 2009,23(6):851-860.
  • 2Sugama S, Takenouchi T, Fujita M, et al. Corticosteroids limit microglial activation occurring during acute stress. Neu- roscience, 2012,232.. 13-20.
  • 3Takasaki I, Kurihara T, Saegusa H, et al. E~~ects of glu- cocorticoid receptor antagonists on allodynia and hyperalgesia in mouse model of neuropathic pain. Eur J Pharmacol, 2005, 524(1-3) .. 80-83.
  • 4Wang S, Lim G, Zeng Q, et al. Central glucocorticoid recep- tors modulate the expression and function of spinal NMDA receptors after peripheral nerve injury. J Neurosci, 2005,25 (2) :488-495.
  • 5Bastos LF, Medeiros DC, Vieira RP, et al. Intraneural dexa- methasone applied simultaneously to rat sciatic nerve con- striction delays the development of hyperalgesia and allodyn- ia. Neurosci Lett, 2012,510(1) ~0-23.
  • 6Wang S, LimG, Zeng Q, et al. Expression of central glu- cocorticoid receptors after peripheral nerve injury contributes to neuropathic pain behaviors in rats. J Neurosci, 2004, 24 (39):8595-8605.
  • 7Decosterd I, Woolf CJ. Spared nerve injury: an animal model of persistent peripheral neuropathic pain. Pain, 2000,87(2).. 149-158.
  • 8Le Coz GM, Anton F, Hanesch U. Glucocorticoid-mediated enhancement of glutamatergic transmission may outweigh an- ti-inflammatory effects under conditions of neuropathic Pain. PLoS One, 2014,9(3) :e91393.
  • 9Gu X, Peng L, Yang D, et al. The respective and interaction effects of spinal GRs and MRs on radicular pain induced bychronic compression of the dorsal root ganglion in the rat. Brain Res, 2011,1396 : 88-95.
  • 10Goodwin JE, FengY, VelazquezH, et al. Loss ofthe endo- thelial glucocorticoid receptor prevents the therapeutic pro- tection afforded by dexamethasone after LP~ PLoS One, 2014,9(10):e108126.

引证文献1

二级引证文献5

当代医学
2010年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部