榆干离褶伞发酵液对急性肝损伤的保护作用

Protective effects of fermentation broth of Lyophyllum ulmarium on mice with acute liver injury

目的:研究榆干离褶伞发酵液对四氯化碳(CCl4)诱发的急性肝损伤的保护作用。方法:用CCl4建立小鼠急性化学性肝损伤模型,检测榆干离褶伞发酵液对血清丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)活性以及肝组织白蛋白(Alb)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)的活力和丙二醛(MDA)的含量。结果:榆干离褶伞发酵液明显降低急性肝损伤小鼠血清ALT活性,提高SOD、GSH-Px活力及Alb含量并显著降低MDA含量。结论:研究榆干离褶伞发酵液具有一定的肝保护作用,其机制可能与其抗氧化作用有关。

Objective：To observe the protective effects of fermentation broth of Lyophyllum ulmarium in mice with acute liver injury induced by CCI4.Methods：The carbon tetrachloride（CCI4） was used to induce the chemical liver injury in mice.The levels of ALT and AST in serum,the activities of SOD,GSH-Px and the concentrations of albumin and MDA in liver homogenates were examined.Results：The experiment showed that the fermentation broth of Lyophyllum ulmarium could reduce the elevated ALT level in serum of mice with liver injury,inhance SOD,GSH-Px activities,increase albumin content and decrease the elevated MDA concentration in the liver tissue.Conclusions：The fermentation broth of Lyophyllum ulmarium has protective effects on the acute chemical liver injury in mice.The effects may be due to its antioxidant activity.