小剂量甲基泼尼松龙治疗重症狼疮性肾炎52例临床分析

A CLINICAL ANALYSIS OF THE TREATMENT OF LUPUS NEPHRITIS WITH LOW-DOSE METHYLPREDNISOLONE (WITH A REPORT OF 52 CASES)

目的探讨治疗狼疮性肾炎更有效的方法。方法将102例狼疮性肾炎随机分为两组。治疗组52例，采用小剂量甲基泼尼松龙静脉滴注，对照组50例口服泼尼极治疗。结果治疗组完全缓解63％、部分缓解23％、无缓解13％，疗效优于对照组。治疗组在纠正免疫学异常、狼疮活动及改善肾功能等方面，与对照组比较，均有显著差异（P＜0．01）。结论小剂量甲基泼尼松龙静滴治疗狼疮性肾炎的疗效优于口服泼尼松，值得推广应用。

Objective To explore more effective methods in the treatment of lupusnephritis. Methods Patients with lupus nephritis were randomly chosen and arranged inthe treatment group (52 cases) and the control group (50 cases). The treatment groupreceived low-dose intravenous methylprednisolone and the control group was treatedwith oral prednisone. Results The complete remission rate, partial remission rate and noresponse rate were 63% 、23% and 13% respectively in the treatment group. The therapeutic effect was better than that in the control group (P<0.01) in correcting immunological abnormality and lupus activities and improving the renal function. Conclusion Patients treated with low-dose methylprednisolone demonstrated a better responsethan those treated with oral prednisone. And this method is worth applying widely.