408株凝固酶阴性葡萄球菌菌谱与耐药性分析

Distribution and drug-resistance of 408 strains coagulase negative stapylococcuse

目的分析医院感染凝固酶阴性葡萄球菌(CNS)的分布及耐药性。方法对2007～2009年医院住院患者各类标本分离到的凝固酶阴性葡萄球菌作药敏试验和甲氧西林耐药性测定。结果在408株CNS中,检出表皮葡萄球菌152株,占37.26%(152/408);耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)286株(70.10%),其中产β-内酰胺酶280株(产酶率97.90%);检出对甲氧西林敏感的凝固酶阴性葡萄球菌(MSCNS)122株(29.90%),其中有17株产β-内酰胺酶(产酶率13.93%),两者比较差异有显著性(P<0.01)。MRCNS对13种抗菌药物耐药性明显高于MSCNS(P<O.01);所有CNS对万古霉素敏感。结论CNS已成为重要医院感染菌;CNS耐药性增高与产β-内酰胺酶有关;临床应积极进行病原学和耐药性监测,合理用药。

Objective To study the distribution and drug resistance of coagluase negative stapylococcuse（CNS）.MethodsThe methicillin-resistance and grug-resistance of the CNS strains isolated from the clinical specimens of the inpatient in our hospital between 2007 to 2009 were tested.ResultsOf all 408 CNS strains of MSCNS,there were 152 S.epidermidis strains,accounting for 37.26%（152/408）,and 286 MRCNS strains in which 280 producing β-lactamase（The positive rate of β-lactamase was 97.9%）,and 122 MSCNS strains（79.90%）including 17 strains which producing β-lactamase（the rate was 13.93%）.Comparing the two,the difference was significant.（P0.01）.The resistance rate of MRCNS to 13 types of antibiotics were higher than those of MSCNS（P0.01）.All CNS was sensitive vancomycin.ConclusionCNS is increasingly playing a significant role in nosocomial infection.The increase of drug resistance of CNS has relation with β-lactamasse;the clinic should monitor the etiology and resistance of CNS,use the drug reasonably.