均匀设计黄芪桂枝五物汤不同剂量配比总黄酮含量的比较研究

Comparison of Flavonoids Content in Huangqi Guizhi Wuwu Tang of Different Dosages by Uniform Design Method

目的:通过对黄芪桂枝五物汤中黄芪、桂枝、白芍、大枣、生姜不同剂量配比中的总黄酮含量测定,分析不同剂量配比中总黄酮含量差异,为确立临床疗效更好的组方建立实验依据。方法:采用均匀设计法设置5因素11水平,考察总黄酮的含量,用计算机处理数据,多元回归分析实验结果。结果:各单味药对总黄酮含量贡献大小分别为黄芪(51.8%)、生姜(0.967%)、大枣(0.689%)、桂枝(0.381%)、白芍(0.185%)。结论:黄酮提取量并不与药物总量成正比,而存在一个最佳剂量配比。

Objective： To determine the content of flavonoids in Huangqi Guizhi Wuwu Tang （HQGZWWT） of different dosages by uniform design method and analyze their difference for clinical application. Methods ： The uniform design set five factors and 11 levels to explore the content of flavonoids. The results were analyzed by computer with the method of multiple regression analysis. Results ： The contribution of each medicinal material to the content of totle flavonoids was Radix Astragali （51.8%）, Rhizoma Zingiberis （0. 967% ）, Rhizoma Zingiberis （0. 689% ）, Ramulus Cinnamomi （0. 381% ） and Raidix Paenoiae alba （0. 185% ）, respectively. Conclusion ： The extraction rate of flavonoids is not directly relative to the total amount of medicines, insteadly, there is an optimum dosage matching for it.