甲型流感病毒基质蛋白2家族的跨种属感染和跨亚型变异的统计学证据(英文)

Statistical Evidence for Cross-Species Infection and Cross-Subtype Mutation in Matrix Protein 2 Family of Influenza A Virus

从统计学视角分析甲型流感病毒基质蛋白2(M 2)的种属差异和亚型差异。首先,用氨基酸对的可预测性将1129个M 2蛋白质转换成1129标量数据,然后用Ⅰ型ANOVA分析这些数据,寻找是否存在种属和亚型的区别,最后用Ⅱ型ANOVA确定组间和组内的差异,进一步追踪跨种属感染和跨亚型突变的原因。得到3条统计学证据,说明甲型流感病毒可能发生跨种属感染和跨亚型突变,其原因是由于各种属和亚型之间的屏障不够强壮,导致突变易于跨越到其它种属或亚型。

The species and subtype differences were analyzed in the matrix 2（M2） proteins of influenza A viruses from a statistical viewpoint.First,the amino-acid pair predictability was used to convert 1129 M2 proteins into 1129 scalar data;Second,the model Ⅰ ANOVA was used to analyze these data in terms of species and subtype in order to find if they are distinguishable;Third,the model Ⅱ ANOVA was used to determine the inter-and intra-species/subtype variations to further trace the reason for cross-species infection and cross-subtype mutation.The results provide three pieces of statistical evidence to demonstrate why the cross-species infection and cross-subtype mutation are possible because the barriers between species and between subtypes are not strong enough,which leads a mutation to easily jump to another species or subtype.