剑麻皂素降血糖作用的研究

Study on Hypoglycemic Effects of Tigogenin

采用四氧嘧啶致糖尿病小鼠模型、肾上腺素引起的高血糖大鼠模型以及正常小鼠研究剑麻皂素的降血糖作用,在口服给药后,测定各模型动物的血糖水平。结果显示,剑麻皂素能明显降低四氧嘧啶糖尿病小鼠的血糖水平,对肾上腺素高血糖大鼠也有降血糖作用,对正常小鼠血糖没有影响。剑麻皂素对糖尿病动物具有明显的降血糖作用。

In order to study the hypoglycemic effects of tigogenin,tigogenin was orally opplied to the diabetic mice induced by alloxan,the hyperglycemic rats induced by adrenaline and the normal mice.The blood glucose levels of mice was determined.Results showed that tigogenin could decrease significantly the blood glucose level of diabetic mice induced by alloxan and the hyperglycemic rats induced by adrenaline but no influence on the blood glucose levels of nomal mice.Therefore,tigogenin had hypoglycemic effects on the diabetic animal models.