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原发性高血压患者血浆脂联素和肿瘤坏死因子-α及相关因子的研究 被引量:8

Clinical Value of Plasma Adiponectin in Patients with Essential Hypertension
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摘要 目的探讨原发性高血压患者是否存在低脂联素血症,以及血脂联素同肿瘤坏死因子-α(Tumor nec-rosis factor,TNF-α)及其他动脉粥样硬化危险因素、血浆生化参数是否存在相关性。方法选取原发性高血压患者55例和健康对照者30例,采用酶联免疫吸附法测定高血压患者血浆脂联素水平,采用放射免疫法测定TNF-α水平,同时监测患者血压、体质指数、空腹血糖及血脂等相关指标。结果原发性高血压患者的血浆脂联素水平显著低于正常对照组,差异有统计学意义(P<0.05),且脂联素水平与TNF-α及其他动脉粥样硬化危险因素如BMI、收缩压、血糖、三酰甘油等呈负相关。多元逐步回归分析表明,血糖和收缩压成为影响原发性高血压患者血浆脂联素水平的独立影响因素。结论原发性高血压患者存在着低脂联素血症,脂联素同其他指标的相关性对临床诊断、治疗有重要指导意义。 Objective To explore whether hypoadiponectinemia is present in patients with essential hypertension and investigate the relationship between adiponectin and TNF-α,other known atherosclerotic risk factors,and plasma biochemical parameters.Methods Totally 55 cases with essential hypertension (HT group) and 30 healthy subjects (control group) were enrolled.Plasma adiponectin was measured by an enzyme-linked immunosorbent assay.TNF-α level was detemined by radioimmunoassay.Other related parameters including blood pressure,body mass index (BMI),fasting blood glucose,and triglyceride were measured or calculated.Results Plasma adiponectin concentration was significantly lower in HT group than in control group.Plasma adiponectin concentration was negatively corrrelated with plasma TNF-αand other risk factors of artherosclerosis such as BMI,systolic blood pressure,blood glucose,and triglyceride (TG).Multiple regression analysis revealed that blood glucose and systolic blood pressure independently affected plasma adiponectin.Conclusion Hypoadiponectinemia exists in patients with essential hypertension.The correlation between adiponectin and other hypertension-related indicators may provide clue for clinical diagnosis and treatment.
出处 《中国全科医学》 CAS CSCD 北大核心 2010年第12期1266-1268,共3页 Chinese General Practice
基金 河北省重大科技攻关计划项目(06276103d) 河北省卫生厅医学科学研究重点课题(06208)
关键词 高血压 肿瘤坏死因子-Α 动脉硬化 Hypertension Tumor necrosis factor-alpha Arteriosclerosis
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参考文献7

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