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B_7-H_4分子在非小细胞肺癌组织中的表达及临床意义 被引量：3

Expression of B_7-H_4 in non-small-cell lung cancer
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摘要 目的:探讨T细胞共刺激分子B7家族成员B7-H4在非小细胞肺癌中的表达及其意义。方法:应用免疫组织化学SP法检测B7-H4分子在80例非小细胞肺癌组织中的表达,并对其表达水平与非小细胞肺癌临床病理参数之间的关系进行相关性分析。结果:B7-H4可表达于肺癌细胞的胞膜、胞浆内或二者均有表达。鳞癌和腺癌患者B7-H4阳性表达率间无显著性差异(P>0.05);发生淋巴结转移和未发生淋巴结转移者B7-H4的阳性表达率间有显著性差异(P<0.05)。结论:B7-H4在非小细胞肺癌组织中的高表达,可能在肿瘤的发生、发展中起到一定作用,有望成为非小细胞肺癌免疫治疗的一个新靶点。 Objective：To study the expression of B7-H4 in non-small-lung cancer and its relationship with cancer clinicopathological variables. Methods：The expression of B7-H4 in 80 surgically resected specmiens of non-small-lung cancer was evaluated immunohistochemically; Furthermore,the correlation between B7-H4 expression and clinicopathological variables was analyzed.Results：In these tumor specmiens,expression of B7-H4 was observed in the cell membrane and/or cytoplasm. There was no significant difference between the patients with squamous cell carcinoma and those with adenocarcinoma in positive expression of B7-H4 （P0.05）. And there was a significant association between the high expression for B7-H4 and lymphnodemetastasis （P0.05）.Conclusion：It is evident that B7-H4 is overexpressed in non-small-cell lung cancer,and it furning plays certain role in oncogenesis and progression of human non-small-cell lung cancer,thus furning into a new target of immunotherapy of non-small-cell lung cancer.
作者 秦旭东 丁伟 姚祖仁 陆海舟
机构地区 江苏省南通市中医院外科 江苏省南通市中医院病理科
出处 《陕西医学杂志》 CAS 2010年第1期19-22,共4页 Shaanxi Medical Journal
关键词 癌 非小细胞肺/病理学 T淋巴细胞 抑制诱导 免疫组织化学 Carcinoma non-small-cell lung/pathology T-lymphocytes suppressor-inducer Immunohistochemistry
分类号 R734.2 [医药卫生—肿瘤]
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参考文献18

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二级参考文献7

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共引文献6

同被引文献20

  • 1刘莉,高建恩,孙启鸿.Neuropilin-1(NRP1)的研究进展[J].细胞与分子免疫学杂志,2007,23(4):383-384. 被引量：5
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二级引证文献5

陕西医学杂志
2010年 第1期

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