头孢曲松与过敏反应关系的文献分析

Literature Review of the Corelation between Ceftriaxone and Ceftriaxone-induced Allergic Reactions

目的:探讨头孢曲松过敏反应的流行病学特点。方法:通过检索1998年1月～2008年6月国内公开发表的有关头孢曲松过敏反应文献报道个案137例,并进行数理统计及分析。结果:头孢曲松过敏反应病例涉及多个器官和(或)系统,前几位分别是皮肤及其附件损害,全身性损害,呼吸系统损害和胃肠系统损害等。全身性损害中又以过敏性休克多见,死亡11例,占总过敏反应的46.97%。发生休克与非休克性过敏反应患者剂量间没有显著性差异。结论:应警惕头孢曲松导致的过敏性休克,大剂量长疗程使用时,应对患者及时进行血液分析及肾功能检测。

Objective：To discuss the epidemiological characteristics of allergic reactions indueed by ceftriaxone. Methods ：137 eeftfiaxone2indueed allergic reaction cases were retrieved from domestic journals reported from Jan. 1998 to Jan. 2008 and statistically analyzed. Results：Ceftriaxone-induced allergic reactions damaged several systems and organs, the top five of whieh were skin lesion and their appendages, clinical body, respiratory system, digestive system, et al, by turns. Anaphylaetic shock, the most common reaction in the systematic reaction, led to 11 death eases （accounting for 46. 97% of allergic reactions）. There was no significant difference between the doses of anaphylaetic shock groups and nonanaphylactie shock groups. Conclusion：Great importance should be attached to the allergic reactions induced by ceftriaxone. Blood analysis and renal function measure should be made when ceftriaxone is used with high dosage or within a long period.